Nerve modulation systems

1. A system for generating a path to a target treatment site within a vertebral body, the system comprising:

an introducer assembly comprising an introducer having a lumen and a first straight stylet;

a curved cannula assembly comprising a cannula and a curved stylet;

a second straight stylet; and

a bipolar radiofrequency (“RF”) energy delivery device having two electrodes configured to deliver energy to the target treatment site,

wherein the first straight stylet is configured for insertion into the lumen of the introducer such that a distal tip of the first straight stylet extends beyond an open distal tip of the introducer,

wherein the cannula comprises an internal passageway and a first alignment member at a proximal portion of the cannula,

wherein the cannula is configured to be inserted within the lumen of the introducer upon removal of the first straight stylet,

wherein a distal portion of the cannula is configured to curve to correspond to a curved distal portion of the curved stylet upon insertion of the curved stylet within the internal passageway of the cannula and advancement of a distal tip of the curved stylet to an open distal tip of the cannula,

wherein the curved stylet comprises a second alignment member configured to be aligned with the first alignment member of the cannula to facilitate proper alignment of corresponding curved distal portions of the cannula and the curved stylet,

wherein the curved cannula assembly is configured to form a curved path toward the target treatment site within an inner cancellous bone region of the vertebral body;

wherein the second straight stylet comprises a flexible channeling stylet configured to be inserted within the internal passageway of the cannula upon removal of the curved stylet,

wherein a distal portion of the second straight stylet is configured to be advanced out of the open distal tip of the cannula to form a linear path beyond the curved path,

wherein the bipolar RF energy delivery device is configured to be inserted within the internal passageway of the cannula upon removal of the second straight stylet, and

wherein the energy delivered by the bipolar RF energy delivery device is configured to heat the target treatment site sufficient to denervate a basivertebral nerve at the target treatment site.

2. The system of claim 1 , wherein the delivered energy is configured to heat the target treatment site sufficient to ablate the basivertebral nerve.

3. The system of claim 1 , wherein the delivered energy is configured to heat the target treatment site sufficient to denervate the basivertebral nerve without necrosis of tissue.

4. The system of claim 1 , wherein the target treatment site is proximal to a junction of the basivertebral nerve.

5. The system of claim 1 , wherein the target treatment site is in a region of the vertebral body located between 60% and 90% of the distance between the anterior and posterior ends of the vertebral body.

6. The system of claim 1 , wherein the first alignment member of the cannula comprises a notch and wherein the second alignment member of the curved stylet comprises an alignment pin.

7. The system of claim 1 , wherein the curved distal portion of the cannula is pre-curved.

8. The system of claim 1 , wherein the distal tip of the first straight stylet is sufficiently sharp to pierce bone tissue.

9. A system for generating a path to a target treatment location within a vertebral body, the system comprising:

an energy delivery device configured to deliver energy to heat the target treatment location;

a cannula having an internal passageway and an opening at a distal tip of the cannula,

wherein a portion of the cannula is curved off axis, thereby facilitating formation of a curved path within the vertebral body toward the target treatment location by a curved stylet inserted through the internal passageway of the cannula;

a straight channeling stylet configured to be inserted through the internal passageway of the cannula after removal of the curved stylet and advanced out of the opening at the distal tip of the cannula to form a linear path to the target treatment location beyond the curved path,

wherein the diameter of the internal passageway of the cannula is configured to receive the energy delivery device,

wherein the cannula has a length sufficient to provide access to the target treatment location within the vertebral body by the energy delivery device,

wherein the target treatment location is within an inner cancellous bone region of the vertebral body, and

wherein the energy is configured to heat the target treatment location sufficient to modulate a basivertebral nerve at the target treatment location.

10. The system of claim 9 , wherein the energy is configured to heat the target treatment location sufficient to ablate the basivertebral nerve.

11. The system of claim 9 , wherein the energy is configured to heat the target treatment location sufficient to denervate the basivertebral nerve without necrosis of tissue.

12. The system of claim 9 , wherein the energy delivery device comprises a bipolar radiofrequency probe comprising two electrodes.

13. The system of claim 9 , wherein the energy delivery device comprises an ultrasound energy delivery device.

14. The system of claim 9 , wherein the opening comprises an axial opening.

15. The system of claim 9 , wherein the opening comprises a radial window.

16. The system of claim 9 , wherein the curved portion of the cannula is pre-curved.

17. A system for generating a path to a target region within bone, the system comprising

a curved cannula assembly comprising a cannula and a curved stylet; and

a straight channeling stylet,

wherein the cannula comprises an internal passageway and a first alignment member at a proximal portion of the cannula,

wherein the cannula comprises a curved distal portion,

wherein the curved stylet comprises a curved distal portion corresponding to the curved distal portion of the cannula,

wherein the curved stylet comprises a second alignment member configured to be aligned with the first alignment member of the cannula to facilitate proper alignment of the corresponding curved distal portions of the cannula and the curved stylet,

wherein the curved cannula assembly is configured to form a curved channel toward the target region within the bone;

wherein the straight channeling stylet is configured to be inserted within the internal passageway of the cannula upon removal of the curved stylet, and

wherein a distal tip of the straight channeling stylet is configured to be advanced out of an open distal tip of the cannula to form a linear channel beyond the curved channel.

18. The system of claim 17 , wherein the curved distal portion of the cannula is pre-curved.

19. The system of claim 17 , further comprising an introducer assembly comprising an introducer having a lumen and a straight sharpened stylet,

wherein the straight sharpened stylet is configured for insertion into the lumen of the introducer such that a distal tip of the straight sharpened stylet extends beyond an open distal tip of the introducer,

wherein the distal tip of the straight sharpened stylet is sufficiently sharp to pierce bone tissue, and

wherein the curved cannula assembly is configured to be delivered to the target region through the lumen of the introducer upon removal of the straight sharpened stylet.

20. The system of claim 17 , further comprising a flexible bipolar radiofrequency (“RF”) energy delivery device having two electrodes configured to deliver energy to the target region,

wherein the energy delivery device is configured to be inserted through the internal passageway of the cannula upon removal of the straight channeling stylet, and

wherein the energy is configured to heat the target region sufficient to ablate an intraosseous nerve within the target region.