IP Library Granted Patent US 8,796,678
Granted Patent B2
US 8,796,678 · App. 14/148,510 · Granted Aug 5, 2014

Platform comprising an organic field-effect transistor for biological and medical applications

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Quick Facts
Patent No.
US 8,796,678
App. No.
14/148,510
Granted
Aug 5, 2014
Kind
B2
Abstract

The present invention relates to a device comprising an organic field effect transistor (OFET) with charge injecting contacts containing a semiconductor layer formed by a perylene derivative, to uses of said device as a medical sensor and/or as a medical cell stimulator and to methods of stimulating and/or monitoring biological cellular activity by using said device.

Claims (36)

1. A device comprising an organic field effect transistor (OFET) with charge injecting contacts, wherein said organic field effect transistor contains a semiconductor layer formed by a diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I)

deposited to cover said charge injecting contacts, of an organic compound selected in the group consisting of diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I) and pentacene.

2. The device according to claim 1 wherein the two alkyl groups at the Nitrogen atoms are n-alkyl groups having the same number of carbon atoms.

3. The device according to claim 2 wherein said n-alkyl groups have 5, 8, 12, 13, 14 or 18 carbon atoms.

4. The device according to claim 1 wherein said diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I) is N,N′-ditridecylperylene-3,4,9,10-tetracarboxylic diimide (P13).

5. The device according to claim 1 wherein said device is a medical sensor.

6. The device according to claim 1 wherein said device is a medical cell stimulator.

7. The device according to claim 1 wherein said device is at the same time a medical sensor and a medical cell stimulator.

8. The device according to claim 1 wherein said organic field effect transistor is an organic light emitting transistor.

9. A method comprising:

providing the device according to claim 5 ; and

using the device as an in vitro sensing system of biological cellular activity.

10. A method comprising:

providing the device according to claim 6 ; and

using the device as an in vitro stimulator for biological cellular activity.

11. A method comprising:

providing the device according to claim 7 ; and

using the device as an in vitro stimulator for biological cellular activity and as an in vitro sensing system of biological cellular activity.

12. The method according to claim 9 wherein said biological cellular activity is neuronal.

13. A method of monitoring biological cellular activity comprising the steps of:

providing the device according to claim 5 ;

depositing a biological cellular material on said diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I);

contacting said device with an aqueous based system; and

monitoring the activity of said biological cellular material.

14. A method of stimulating biological cellular activity comprising the steps of:

providing a device according to claim 6 ;

depositing a biological cellular material on said diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I);

contacting said device with an aqueous based system; and

driving the device to stimulate the activity of said biological cellular material.

15. A method of stimulating biological cellular activity and monitoring said biological cellular material, comprising the steps of:

providing a device according to claim 7 ;

depositing a biological cellular material on said diimmide perylene derivative (PTCDI), substituted with alkyl groups at the Nitrogen atoms, according to formula (I);

contacting said device with an aqueous based system;

driving the device to stimulate the activity of said biological cellular material; and

monitoring the activity of said biological cellular material.

16. The method according to claim 13 wherein said biological cellular material comprises neurons.

Assignments (8)
ASSET PURCHASE AGREEMENT Recorded Dec 13, 2025
From: FLEXTERRA, INC.; FLEXTERRA TAIWAN CORPORATION LIMITED
To: USINVEST, LLC
Reel/Frame 073948/0751 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2025
From: FLEXTERRA, INC.
To: USINVEST LLC
Reel/Frame 073464/0376 →
SECURITY INTEREST Recorded Oct 17, 2024
From: FLEXTERRA, INC.
To: SAES GETTERS INTERNATIONAL LUXEMBOURG S.A., IN ITS CAPACITY AS COLLATERAL AGENT
Reel/Frame 069191/0563 →
SECURITY INTEREST Recorded Aug 10, 2021
From: FLEXTERRA, INC.
To: SAES GETTERS INTERNATIONAL LUXEMBOURG S.A., IN ITS CAPACITY AS COLLATERAL AGENT
Reel/Frame 057136/0437 →
CHANGE OF NAME Recorded Nov 16, 2020
From: E.T.C. S.R.L.
To: E.T.C. S.R.L. IN LIQUIDAZIONE
Reel/Frame 054370/0092 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2020
From: E.T.C. IN LIQUIDAZIONE
To: FLEXTERRA, INC.
Reel/Frame 054004/0974 →
CHANGE OF ASSIGNEE'S ADDRESS Recorded Feb 1, 2017
From: E.T.C. S.R.L.
To: E.T.C. S.R.L.
Reel/Frame 041590/0071 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2014
From: CAPELLI, RAFFAELLA; TOFFANIN, STEFANO; BENFENATI, VALENTINA; MUCCINI, MICHELE; ZAMBONI, ROBERTO; GENERALI, GIANLUCA
To: E.T.C. S.R.L.
Reel/Frame 031907/0763 →