Devices for delivering oxygen to the wounds
View Patent ↗The present invention comprises methods and compositions for delivery devices More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.
1. An oxygen-delivery wound treatment device, the device comprising:
a) a formed biocompatible matrix, wherein the matrix is a closed cell foam, the matrix comprising: a cross-linked polymer present in an amount ranging from about 2.5 wt. % to 10 wt. % based on the total weight of the matrix and a non-gellable polysaccharide present in an amount ranging from 0.25 wt. % to 5 wt. % based on the total weight of the matrix, wherein the cross-linked polymer comprises polyacrylamide cross-linked with 0.025 wt. % to 0.15 wt % bis-acrylamide based on the total weight of the matrix and the non-gellable polysaccharide comprises guar gum, wherein the matrix includes closed cells and walls;
b) gaseous oxygen, wherein the gaseous oxygen is contained in the closed cells;
c) dissolved oxygen, wherein the dissolved oxygen is present in the walls, wherein the gaseous oxygen and the dissolved oxygen are formed by a reaction between a peroxide and a catalyst; and
d) water, wherein the water is present in the walls, wherein the oxygen delivery wound treatment device delivers oxygen to a wound site or compromised tissue.
2. The device of claim 1 , further comprising at least one active agent.
3. The device of claim 1 , wherein the matrix comprises a stranded configuration.
4. The device of claim 1 , further comprising a water loss control agent, wherein the water loss control agent comprises petrolatum, glycolipids, ceramides, free fatty acids, cholesterol, triglycerides, sterylesters, cholesteryl sulfate, linoleic ethyl ester, silicone oil, or a combination thereof, wherein the water loss control agent is applied to a surface of the device.
5. The device of claim 1 , wherein the matrix further comprises a plasticizer, wherein the plasticizer comprises glycerol, propylene glycol, butanol, or a combination thereof.
6. The device of claim 1 , wherein the matrix further comprises a hydration control agent, wherein the hydration control agent comprises isopropyl alcohol, ethanol, glycerol, butanol, propylene glycol, or a combination thereof.
7. The device of claim 1 , wherein the oxygen-delivery wound treatment device maintains delivery of oxygen for at least 24 hours.
8. An oxygen-delivery wound treatment device, the device comprising:
a) a formed biocompatible matrix, wherein the matrix is a closed cell foam, the matrix comprising: a cross-linked polymer present in an amount ranging from about 2.5 wt. % to 10 wt. % based on the total weight of the matrix and a non-gellable polysaccharide present in an amount ranging from 0.25 wt. % to 5 wt. % based on the total weight of the matrix, wherein the cross-linked polymer comprises polyacrylamide cross-linked with 0.025 wt. % to 0.15 wt. % bis-acrylamide based on the total weight of the matrix and the non-gellable polysaccharide comprises guar gum, wherein the matrix includes closed cells and walls;
b) gaseous oxygen, wherein the gaseous oxygen is contained in the closed cells;
c) dissolved oxygen, wherein the dissolved oxygen is present in the walls, wherein the gaseous oxygen and the dissolved oxygen are formed by a reaction between a peroxide and a catalyst; and
d) water, wherein the water is present in the walls, wherein the oxygen-delivery wound treatment device maintains delivery of oxygen for at least 24 hours, wherein the oxygen delivery wound treatment device delivers oxygen to a wound site or compromised tissue.