IP Library Granted Patent US 10,499,819
Granted Patent B2
US 10,499,819 · App. 14/150,625 · Granted Dec 10, 2019

Breath selection for analysis

Inventors: Anthony D. Wondka (San Ramon, CA); Anish Bhatnagar (Redwood City, CA); Scott J. Gilbert (Menlo Park, CA)
Assignee: CAPNIA, INC.
A61B5/02055A61B5/082A61B5/7221A61B5/7275G16H10/40G16H40/63G16H50/20A61B5/01A61B5/087A61B5/0816A61B5/091A61B5/7203A61B5/7285A61B2560/0223
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Quick Facts
Patent No.
US 10,499,819
App. No.
14/150,625
Granted
Dec 10, 2019
Kind
B2
Abstract

Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Claims (20)

1. An apparatus for analyzing an exhaled breath, comprising:

a sensor;

a breath sampling system;

a gas analyzer; and

a control system comprising a processor that operates the sensor, the breath sampling system, and the gas analyzer using a plurality of algorithms,

wherein the sensor measures a first parameter of a first exhaled breath to determine a threshold criteria according to a first algorithm run by the processor, the sensor also measuring a second parameter of a next exhaled breath,

wherein the breath sampling system captures the next exhaled breath according to a second algorithm run by the processor when the second parameter meets the threshold criteria, or initiates capture of an alternative breath according to a third algorithm when the threshold criteria are not met, and

wherein the gas analyzer

applies a gas sampling and analysis algorithm to the captured next exhaled breath, and applies a correction factor to the gas sampling and analysis algorithm for the captured alternative breath.

2. The apparatus of claim 1 , further comprising a physiologic sensor that monitors a physiological parameter of a patient, wherein the breath sampling system captures the next exhaled breath when a fourth algorithm determines the physiological parameter meets a predetermined physiological criteria.

3. The apparatus of claim 2 , wherein the physiologic parameter comprises at least one selected from the group consisting of a blood pressure, a heart rate, chest impedance, a weight, a height, an age, a race, a sex, a diagnosis, a respiratory rate, a tidal volume, a minute volume, an inspiratory:expiratory ratio, a blood gas, a cardiac output, an end tidal CO 2 concentration, a pulmonary perfusion, a base excess, an O 2 saturation, and a ventilation:perfusion ratio.

4. The apparatus of claim 1 , wherein the predetermined criteria comprises a minimum duration.

5. The apparatus of claim 1 , wherein the predetermined criteria comprises at least one selected from the group consisting of: a peak amplitude value, a baseline value, a time duration above the peak amplitude value, a time duration below the baseline value, and a percent comparison of a current breath to a trending algorithm.

6. The apparatus of claim 1 , wherein the predetermined criteria comprises an amplitude value and a baseline value representing a complete tidal volume breath.

7. The apparatus of claim 1 , wherein the predetermined criteria comprises a breath rate of less than or equal to 60 breaths per minute.

8. The apparatus of claim 1 , wherein the threshold criteria are based on at least one selected from the group consisting of an expiratory time, a portion of an expiratory time, an airway pressure, a CO 2 value over time, an O 2 value over time, an airway temperature, a breath flow rate, a breath rate, a depth of breath, a duration of breath, an inspiratory time, a pre-end-tidal time, an end-tidal time, a post-expiratory time, an inspiratory pause, a peak inspiratory pressure, a peak expiratory pressure, a characteristic waveform for sneeze, cough, stacked breath or non-full breath, an inspiratory amplitude, an expiratory amplitude, and a historical breath criteria.

9. The apparatus of claim 1 , wherein the predetermined criteria is based upon at least one selected from the group consisting of a breath hold, a deep breath, a forced exhaled breath, an inspiratory pause, an expiratory pause, a resting respiration, and a breath pattern repetition.

10. The apparatus of claim 1 , wherein the predetermined criteria is based upon a predetermined number of repetitive breaths.

11. The apparatus of claim 10 , wherein the number of repetitive breaths is between 1 and 5 breaths.

12. The apparatus of claim 10 , wherein the number of repetitive breaths is between 2 and 4 breaths.

Assignments (4)
SECURITY INTEREST Recorded Dec 17, 2024
From: SOLENO THERAPEUTICS, INC.; ESSENTIALIS, INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 069613/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2018
From: SOLENO THERAPEUTICS, INC.
To: CAPNIA, INC.
Reel/Frame 046295/0146 →
CHANGE OF NAME Recorded Nov 17, 2017
From: CAPNIA, INC.
To: SOLENO THERAPEUTICS, INC.
Reel/Frame 044784/0981 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2015
From: WONDKA, ANTHONY D.; BHATNAGAR, ANISH; GILBERT, SCOTT J.
To: CAPNIA, INC.
Reel/Frame 034943/0103 →
Continuity (2)
Provisional Application 61750305 · Jan 8, 2013
Related Publication 20140194703A1 · Jul 10, 2014