Therapeutic compounds

1. A compound of formula I:

wherein:

A is a 5-membered N-heteroaryl, wherein the 5-membered N-heteroaryl is substituted with one Z 1 group and optionally substituted with 1, 2, or 3 Z 2 groups;

R 1 is a bicyclic-heteroaryl or tricyclic heteroaryl, wherein the bicyclic-heteroaryl has 4 to 12 carbon atoms and 1-5 heteroatoms, and wherein any bicyclic-heteroaryl of R 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 3 groups;

R 2 is a phenyl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any phenyl, 5-membered heteroaryl or 6-membered heteroaryl of R 2 is optionally substituted with 1, 2, 3, 4 or 5 Z 4 groups;

Z 1 is selected from (C 3 -C 8 )alkyl, (C 6 -C 20 )aryl,and aryl(C 1 -C 6 )alkyl-, wherein any aryl, and aryl(C 1 -C 6 )alkyl- of Z 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a or Z 1b groups and wherein any (C 3 -C 8 )alkyl of Z 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 1a groups;

each Z 1a is independently selected from (C 3 -C 7 )carbocycle, halogen, —CN, —OR n1 , —OC(O)R p1 , —OC(O)NR q1 R r1 , —SR n1 , —S(O)R p1 , —S(O) 2 OH, —S(O) 2 R p1 , —S(O) 2 NR q1 R r1 , —NR q1 R r1 , —NR n1 COR p1 , —NR n1 CO 2 R p1 , —NR n1 CONR q1 R r1 , —NR n1 S(O) 2 R p1 , —NR n1 S(O) 2 OR p1 , —NR n1 S(O) 2 NR q1 R r1 , NO 2 , —C(O)R n1 , —C(O)OR n1 and —C(O)NR q1 R r1 ;

each Z 1b is independently selected from (C 1 -C 6 )alkyl and (C 3 -C 5 )carbocycle wherein any (C 1 -C 6 )alkyl and (C 3 -C 5 )carbocycle of Z 1b is optionally substituted with 1, 2, 3, 4, or 5 halogen;

each Z 2 is independently selected from (C 1 -C 3 )alkyl, (C 1 -C 3 )haloalkyl, halogen and —O(C 1 -C 3 )alkyl;

each Z 3 is independently selected from (C 1 -C 6 )alkyl, (C 3 -C 7 )carbocycle, halogen, —CN, —OR n2 , —OC(O)R p2 , —OC(O)NR q2 R r2 , —SR n2 , —S(O)R p2 , —S(O) 2 OH, —S(O) 2 R p2 , —S(O) 2 NR q2 R r2 , —NR q2 R r2 , —NR n2 COR p2 , —NR n2 CO 2 R p2 , —NR n2 CONR q2 R r2 , —NR n2 S(O) 2 R p2 , —NR n2 S(O) 2 OR p2 , —NR n2 S(O) 2 NR q2 R r2 , NO 2 , —C(O)R n2 , —C(O)OR n2 and —C(O)NR q2 R r2 , wherein any (C 3 -C 7 )carbocycle and (C 1 -C 6 )alkyl of Z 3 is optionally substituted with 1, 2, 3, 4, or 5 halogen;

each Z 4 is independently selected from (C 1 -C 6 )alkyl, halogen and —OR n3 , wherein any (C 1 -C 6 )alkyl of Z 4 is optionally substituted with 1, 2, 3, 4, or 5 halogen;

each R n1 is independently selected from H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle;

each R p1 is independently selected from (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle;

R q1 and R n1 are each independently selected from H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle, or R q1 and R r1 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle;

each R n2 is independently selected from H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle;

each R p2 is independently selected from (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle;

R q2 and R r2 are each independently selected from H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl and (C 3 -C 7 )carbocycle, or R q2 and R r2 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle; and

each R n3 is independently selected from H, (C 1 -C 3 )alkyl, (C 1 -C 3 )haloalkyl, and (C 3 -C 7 )carbocycle;

or a salt thereof.

2. The compound of claim 1 , or a salt thereof, wherein A is selected from imidazol-2-yl, 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl, thiazol-4-yl, thiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-oxadiazol-5-yl, oxazol-5-yl, isoxazol-3-yl, imidazol-4-yl and oxazol-4-yl, wherein imidazol-2-yl, 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl, thiazol-4-yl, thiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,4-oxadiazol-5-yl, oxazol-5-yl, isoxazol-3-yl, imidazol-4-yl and oxazol-4-yl are each substituted with one Z 1 group and optionally substituted with 1, 2, or 3 Z 2 groups.

3. The compound of claim 1 , or a salt thereof, wherein A is:

wherein the dashed bond is a single or double bond so that ring A is aromatic, A is substituted with one Z 1 group and optionally substituted with 1, 2, or 3 Z 2 groups.

4. The compound of claim 1 , or a salt thereof, wherein A is:

wherein the dashed bonds are single or double bonds so that ring A is aromatic, X is N or C, and wherein A is optionally substituted with 1, 2, or 3 Z 2 groups.

5. The compound of claim 1 , or a salt thereof, wherein A is:

wherein X is N or C, each X 1 is independently selected from N, NZ 2a , O, S and CZ 2a , the dashed bonds are selected from single and double bonds so that ring A is aromatic, and Z 2a is selected from H and Z 2 .

6. The compound of claim 1 , or a salt thereof, wherein A is selected from

wherein each Z 2a is independently selected from Z 2 and H.

7. The compound of claim 1 , or a salt thereof, wherein each Z 1a is independently selected from halogen and —OR n1 , each Z 1b is (C 1 -C 6 ) alkyl, and wherein R n1 is (C 1 -C 6 )alkyl.

8. The compound of claim 1 , or a salt thereof, wherein A is selected from

9. The compound of claim 1 , or a salt thereof, wherein R 2 is phenyl optionally substituted with 1, 2, 3, 4, or 5 Z 4 groups.

10. The compound of claim 1 , or a salt thereof, wherein each Z 4 is halogen.

11. The compound of claim 1 , or a salt thereof, wherein R 1 is selected from indolyl, 4,5,6,7-tetrahydro-indazolyl, benzo[d]imidazolyl and pyrrolo[3,2-b]pyridinyl, wherein any indolyl, 4,5,6,7-tetrahydro-indazolyl, benzo[d]imidazolyl and pyrrolo[3,2-b]pyridinyl of R 1 is optionally substituted with 1, 2, 3, 4, or 5 Z 3 groups.

12. The compound of claim 1 , or a salt thereof, wherein each Z 3 is independently selected from fluoro, hydroxy, trifluoromethyl, methyl and methoxy.

13. The compound of claim 1 , or a salt thereof, wherein R 1 is selected from:

14. The compound of claim 1 selected from:

and salts thereof.

15. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.