Enhanced clearance in an artificial kidney incorporating a pulsatile pump
A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between −10 and 10 mmHg for a first time period and a low differential pressure of between −10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.
1. A method of dialysis comprising:
receiving blood in a blood circuit of a dialysis device;
pumping the blood in a pulsed manner to provide an average pulsatile blood flow rate of between 30 and 90 ml/min;
pumping dialysate, in a dialysate circuit of said dialysis device, in a pulsed manner to provide an average pulsatile dialysate flow rate of between 30 and 90 ml/min;
receiving said pumped blood at a blood inlet of a dialyzer; and
receiving said pumped dialysate at a dialysate inlet of said dialyzer, wherein a pressure differential between said blood in said blood inlet and said dialysate in said dialysate inlet fluctuates at a periodic rate between 0 mmHg+/−10 mmHg and 120 mmHg+/−20 mmHg; and
transferring urea molecules from said blood to said dialysate while said blood and said dialysate are passing through said dialyzer;
cleaning said dialysate by a filtration means, said cleaned dialysate being recirculated in said dialysate circuit.
2. The method of claim 1 , wherein cleaning said dialysate further comprises regenerating said dialysate by adding predetermined additives to said dialysate.
3. The method of claim 1 , wherein said periodic rate is between 0.5 and 4 Hz.
4. The method of claim 1 , wherein said method is provided by at least one of a completely wearable and a portable dialysis device.
5. The method of claim 1 , wherein said pumping of said blood further comprises pumping of said blood by a first channel of a dual channel pulsatile pump and said pumping of said dialysate further comprises pumping of said dialysate by a second channel of said dual channel pulsatile pump.
6. The method of claim 1 , wherein said dual channel pulsatile pump pumps said blood and pumps said dialysate such that a peak flow of said blood occurs in an alternating pattern with a peak flow of said dialysate.
7. The method of claim 1 , wherein said pumping said blood in a pulsed manner comprises providing in an alternating manner a high blood flow rate portion and a low blood flow portion, and wherein said pumping dialysate in a pulsed manner comprises providing in an alternating manner a high dialysate flow rate portion and a low dialysate flow rate portion, said high blood flow rate portion and said low dialysate flow rate portion each occurring, at least for a majority of their durations, at the same time.