IP Library › Granted Patent US 9,572,840
Granted Patent B2
US 9,572,840 · App. 14/152,649 · Granted Feb 21, 2017

Regeneration and repair of neural tissue using postpartum-derived cells

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Quick Facts
Patent No.
US 9,572,840
App. No.
14/152,649
Granted
Feb 21, 2017
Kind
B2
Abstract

Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

Claims (7)

1. A method of providing factors to a patient having a neurodegenerative condition comprising administering to the patient a composition comprising a conditioned medium generated by culturing cells isolated from human umbilical cord tissue substantially free of blood, wherein said cells are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a neural phenotype; exhibit the ability to undergo at least about 40 doublings in culture without a change in karyotype, and lack production of CD117; and wherein the method promotes cell survival and/or neuronal differentiation and wherein the factors are selected from the group consisting of brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), granulocyte chemotactic protein-2 (GCP-2), transforming growth factor beta2 (TGFbeta2), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), keratinocyte growth factor (KGF), platelet derived growth factor (PDGF-bb), heparin-binding epidermal growth factor (HB-EGF) and combinations thereof.

2. The method of claim 1 , wherein said cells produce each of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, PD-L2 and HLA-A,B,C.

3. The method of claim 1 , wherein said cells lack the production of CD31, CD34, CD45, CD80, CD86, CD141, CD178, B7-H2, HLA-G and HLA-DR,DP,DQ.

4. The method of claim 1 , wherein said cells secrete each of the factors MCP-1, IL-6, IL-8, GCP-2, HGF, KGF, FGF, HB-EGF, BDNF, TPO and TIMP1.

5. The method of claim 1 , wherein said cells do not secrete one or more of the factors SDF-1 alpha, TGF-beta2, ANG2, PDGFbb and VEGF.

6. The method of claim 1 , wherein the method promotes cell survival.

7. The method of claim 1 , wherein the method promotes neuronal differentiation.