IP Library Granted Patent US 10,588,586
Granted Patent B2
US 10,588,586 · App. 14/155,393 · Granted Mar 17, 2020

Cardiac analysis based on vessel characteristics

Inventor: Hongxuan Zhang (Palatine, IL)
Assignee: Siemens Healthcare GmbH
A61B6/504A61B6/481A61B6/486A61B6/507A61B6/5217A61B6/5288G06T7/62A61B5/02007A61B5/055A61B6/032A61B6/037A61B6/4441G01R33/5635G06T2207/30101
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Quick Facts
Patent No.
US 10,588,586
App. No.
14/155,393
Granted
Mar 17, 2020
Kind
B2
Abstract

A system and method includes reception of a first image of a blood vessel, reception of a second image of the blood vessel, determination of a first size of a region of the blood vessel based on the first image, determination of a second size of the region of the blood vessel based on the second image, and calculation of a parameter of the blood vessel based on the first size and the second size.

Claims (46)

1. A system comprising:

an interface configured to receive a first plurality of images of a blood vessel, and to receive a second plurality of images of the blood vessel; and

a storage device configured to store program code executable by an image data processor to cause the image data processor to:

determine a first plurality of respective sizes of a region of the blood vessel based on respective ones of the first plurality of images;

determine a second plurality of respective sizes of a region of the blood vessel based on respective ones of the second plurality of images;

calculate respective vessel contraction/expansion energy ratios based on at least one of the first plurality of respective sizes and at least one of the second plurality of respective sizes, the respective vessel contraction/expansion energy ratios each representing a ratio of an integral across multiple time regions for a duration associated with systole to the integral across multiple time regions for a duration associated with diastole;

combine the respective vessel contraction/expansion energy ratios to form a universal ratio representing a summation of a plurality of respective products, each of the respective products being a product of each of the respective vessel contraction/expansion energy ratios multiplied by at least one calculation coefficient over increments of the blood vessel region;

analyze the respective vessel contraction/expansion energy ratios to characterize a presence of at least one of a cardiac functional abnormality and an arrhythmia;

display a result of the analysis on a display device of a terminal in communication with the image data processor, the display result including at least one of a mapping of an artery tree and a cardiac coronary artery matrix; and

the artery tree mapping and the cardiac coronary artery matrix including an identification of a potential pathological position of at least one specific myocardial ischemic location in at least one of an artery and an artery branch, the myocardial ischemic location position based on a result of the analysis.

2. The system of claim 1 , the artery tree depicting at least one of contraction and perfusion within an artery represented in the artery tree.

3. The system of claim 1 , the image data processor further to analyze the respective vessel contraction/expansion energy ratios by comparison to a normal healthy mean value.

4. The system of claim 1 , the image data processor further to determine from at least one of the first and at least one of the second plurality of respective sizes a respective blood vessel diameter ratio of the region of the blood vessel; and

apply the respective blood vessel diameter ratio in the analysis of the respective vessel contraction/expansion energy ratios.

5. The system of claim 1 , including:

the first plurality of images acquired at substantially a same respective first point in a physiological cycle;

the second plurality of images acquired at substantially a same respective second point in a physiological cycle; and

determination of the first and the second plurality of respective sizes includes determination of one or more respective cross-sectional areas of the region of the blood vessel at the respective first and the respective second points.

6. The system of claim 5 , wherein each of the plurality of images is associated with a different projection angle.

7. The system of claim 5 , the image data processor further to calculate respective blood vessel inflation-to-heart rate ratios based on the respective cross-sectional areas at the respective first and the respective second points in the physiological cycle.

8. The system of claim 1 , the first image depicting the blood vessel at substantially maximum blood pressure, and the second image depicting the blood vessel at substantially minimum blood pressure.

9. A method comprising:

receiving a first plurality of images of a blood vessel;

receiving a second plurality of images of the blood vessel;

determining a first plurality of respective sizes of a region of the blood vessel based on respective ones of the first plurality of images;

determining a second plurality of respective sizes of the region of the blood vessel based on respective ones of the second plurality of images;

calculating respective vessel contraction/expansion energy ratios based on at least one of the first plurality of respective sizes and at least one of the second plurality of respective sizes, the respective vessel contraction/expansion energy ratios each representing a ratio of an integral across multiple time regions for a duration associated with systole to the integral across multiple time regions for a duration associated with diastole;

combining the respective vessel contraction/expansion energy ratios to form a universal ratio representing a summation of a plurality of respective products, each of the respective products being a product of each of the respective vessel contraction/expansion energy ratios multiplied by at least one calculation coefficient over increments of the blood vessel region;

analyzing the respective vessel contraction/expansion energy ratios to characterize a presence of at least one of a cardiac functional abnormality and an arrhythmia;

displaying a result of the analysis on a display device of a terminal in communication with the image data processor, the display result including at least one of a mapping of an artery tree and a cardiac coronary artery matrix; and

the artery tree mapping and the cardiac coronary artery matrix including an identification of a potential pathological position of at least one specific myocardial ischemic location in at least one of an artery and an artery branch, the myocardial ischemic location position based on a result of the analysis.

10. The method of claim 9 , further comprising:

the artery tree depicting at least one of contraction and perfusion within an artery represented in the artery tree.

11. The method of claim 9 , further comprising:

analyzing the respective vessel contraction/expansion energy ratios by comparison to a normal healthy mean value.

12. The method of claim 9 , further comprising:

determining from at least one of the first and at least one of the second plurality of sizes a respective blood vessel diameter ratio of the region of the blood vessel; and

applying the respective blood vessel diameter ratio in the analysis of the respective vessel contraction/expansion energy ratios.

13. The method of claim 9 , including:

acquiring the first plurality of images at substantially a same respective first point in a physiological cycle,

acquiring the second plurality of images at substantially a same respective second point in a physiological cycle; and

determining the first and the second plurality of respective sizes includes determining one or more respective cross-sectional areas of the region of the blood vessel at the respective first and the respective second points.

14. The method of claim 13 , wherein each of the plurality of images is associated with a different projection angle.

15. The method of claim 13 , further comprising:

calculating respective blood vessel inflation-to-heart rate ratios based on the respective cross-sectional areas at the respective first and the respective second points in the physiological cycle.

16. The method of claim 9 , the first image depicting the blood vessel at substantially maximum blood pressure, and the second image depicting the blood vessel at substantially minimum blood pressure.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE PREVIOUSLY RECORDED AT REEL: 066088 FRAME: 0256. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jan 17, 2024
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 071178/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2023
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066088/0256 →
CORRECTIVE ASSIGNMENT TO CORRECT THE EXECUTION DATE OF ASSIGNMENT 3, ASSIGNOR SIEMENS MEDICAL SOLUTIONS USA, INC. TO SIEMENS HEALTHCARE GMBH PREVIOUSLY RECORDED ON REEL 043379 FRAME 0673. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF INVENTOR RIGHTS.. Recorded Dec 2, 2020
From: SIEMENS MEDICAL SOLUTIONS USA, INC.
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 056112/0540 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2017
From: SIEMENS MEDICAL SOLUTIONS USA, INC.
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 043379/0673 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2014
From: ZHANG, HONGXUAN
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 031969/0104 →
Continuity (2)
Provisional Application 61753024 · Jan 16, 2013
Related Publication 20140200461A1 · Jul 17, 2014