IP Library Granted Patent US 9,463,164
Granted Patent B2
US 9,463,164 · App. 14/160,861 · Granted Oct 11, 2016

Tablet having improved elution properties

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Quick Facts
Patent No.
US 9,463,164
App. No.
14/160,861
Granted
Oct 11, 2016
Kind
B2
Abstract

The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof. A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating. A production method of a film-coated tablet, including a step of producing the granulated particles, a step of producing a tablet by mixing with the later powder and forming the mixture, and a step of applying a film coating to the obtained tablet.

Claims (4)

1. A tablet free of film coating obtained by mixing granulated particles obtained by granulating a mixture of (a) (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof, (b′) one or more kinds of fillers selected from lactose and crystalline cellulose, (c) a cellulose-based disintegrant, (d) one or more kinds of water-soluble binders selected from polyvinyl alcohol, hydroxypropylcellulose and hypromellose 2910, and (g) natural starch.

2. The tablet according to claim 1 , wherein the filler of the aforementioned (b′) is lactose.

3. The tablet according to claim 1 , showing good dissolution property.

4. The tablet according to claim 1 , further comprising a lubricant.

Assignments (1)
CHANGE OF NAME Recorded Aug 15, 2014
From: DAINIPPON SUMITOMO PHARMA CO., LTD.
To: SUMITOMO DAINIPPON PHARMA CO., LTD.
Reel/Frame 033550/0066 →