IP Library Granted Patent US 9,061,020
Granted Patent B2
US 9,061,020 · App. 14/162,723 · Granted Jun 23, 2015

PPAR gamma agonists for treatment of multiple sclerosis

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Quick Facts
Patent No.
US 9,061,020
App. No.
14/162,723
Granted
Jun 23, 2015
Kind
B2
Abstract

Methods of treatment of multiple sclerosis (MS) with PPARγ agonists, and in particular with the compound of formula (I) known as INT131:

Claims (8)

1. A method of treating relapsing and remitting multiple sclerosis (RRMS) in a patient in need thereof comprising administering to said patient at regular dosing intervals of a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I),

or a pharmaceutically acceptable salt, prodrug, or isomer thereof.

2. A method of treating the symptoms of RRMS comprising administering to a patient in need thereof a compound of formula (I),

or a pharmaceutically acceptable salt, prodrug or isomer thereof

3. A method of providing neuroprotection to a patient with gray matter atrophy comprising administering a compound of the formula (I),

or a pharmaceutically acceptable salt, prodrug or isomer thereof.

4. A method of treating the symptoms of neuroinflammation comprising administering to a patient in need thereof a compound of formula (I),

or a pharmaceutically acceptable salt, prodrug or isomer thereof.

Assignments (6)
TERMINATION AND RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 59436/0055 Recorded May 9, 2024
From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
To: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
Reel/Frame 067378/0256 →
SECURITY INTEREST Recorded May 8, 2024
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.; SURFACE ONCOLOGY, LLC; COHERUS ONCOLOGY SUPPORTIVE CARE LLC
To: ANKURA TRUST COMPANY, LLC
Reel/Frame 067348/0160 →
SECURITY INTEREST Recorded Mar 18, 2022
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 059436/0055 →
RELEASE OF NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS AT REEL/FRAME NO. 048021/0975 Recorded Jan 11, 2022
From: HCR COLLATERAL MANAGEMENT, LLC
To: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
Reel/Frame 058692/0665 →
SECURITY INTEREST Recorded Jan 7, 2019
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
To: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 048021/0975 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2014
From: WEINSTEIN, DAVID
To: INTEKRIN THERAPEUTICS, INC.
Reel/Frame 032166/0840 →