Methods and devices for evaluating and treating a bone condition based on X-ray image analysis
View Patent ↗The present invention relates to methods and devices for evaluating bone conditions based on images. In particular, devices, methods and algorithms are provided that allow for the accurate and reliable evaluation of bone structure from x-ray images.
1. A method of evaluating a bone condition in a subject comprising:
(a) analyzing, using a computer system, an image of a bone of the subject;
(b) deriving quantitative information on bone structure from a sliding region of interest (ROI) on the image; and
(c) determining the bone condition based on the quantitative information.
2. The method of claim 1 , wherein the bone structure includes trabecular bone structure.
3. The method of claim 1 , wherein the quantitative information on bone structure includes one or more bone microarchitecture parameters.
4. The method of claim 1 , wherein the quantitative information on bone structure includes one or more bone macroanatomical parameters.
5. The method of claim 1 , wherein the quantitative information on bone structure includes a single index of combined bone structure parameters.
6. The method of claim 1 , further comprising comparing the quantitative information with information in a database of bone structure measurements obtained from selected subjects.
7. The method of claim 1 , wherein the determining comprises diagnosing bone disease.
8. The method of claim 7 , further comprising:
assessing one or more macro-anatomical parameters in said image,
assessing bone mineral density and bone structure parameters in said image, and
combining the assessments to diagnose the bone disease.
9. The method of claim 1 , wherein the determining comprises monitoring progression of bone disease.
10. The method of claim 1 , further comprising selecting a therapy based on the bone condition and administering said therapy to said subject.
11. The method of claim 10 , wherein the determining comprises monitoring progression of bone disease during or after administration of said selected therapy.
12. A method of evaluating, using a computer system, bone disease in a subject, the method comprising the steps of:
(a) analyzing, using a computer system, an image of a bone of the subject;
(b) assessing bone mineral density in at least one sliding ROI of said image;
(c) assessing bone structure in said sliding ROI; and
(d) combining said assessments of bone mineral density and bone structure to evaluate bone disease.
13. The method of claim 12 , wherein said bone disease comprises risk of bone fracture or risk of osteoporotic fracture.
14. The method of claim 12 , wherein said evaluation comprises diagnosing bone disease.
15. The method of claim 14 , wherein said bone disease comprises risk of bone fracture or risk of osteoporotic fracture.
16. The method of claim 12 , wherein said evaluation comprises monitoring progression of bone disease.
17. The method of claim 14 , further comprising selecting a therapy based on the evaluation of bone disease and administering said therapy to said subject.
18. The method of claim 17 , wherein said evaluation comprises monitoring progression of bone disease during or after administration of said selected therapy.
19. The method of claim 12 , further comprising:
assessing one or more macro-anatomical parameters in said image, and
combining said assessment of bone mineral density, bone structure and macro-anatomical parameters to diagnose bone disease.