Methods for modifying vascular vessel walls
View Patent ↗This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
1. A method of treating a vascular vessel of a patient, the method comprising:
accessing a treatment site proximate to a defect in a vascular vessel;
placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site;
placing a reinforcing clamp around said biomaterial to provide further support or compress against the external side walls of said vascular vessel; and
wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation so as to modify the shape of and support the vessel wall at the treatment site.
2. The method of claim 1 , wherein said remodelable biomaterial is placed so as to partially or fully encircle the exterior of a vessel wall at the treatment site.
3. The method of claim 1 , wherein said remodelable biomaterial is sutured or secured to the external circumference of the target vessel overlaying the treatment site.
4. The method of claim 1 , wherein opposite ends of said remodelable biomaterial touch or overlap each other.
5. The method of claim 1 , wherein two portions of said remodelable biomaterial are secured together.
6. The method of claim 5 , wherein the two portions of said remodelable biomaterial are secured together by suturing, tissue welding, the use of bonding agents, or the use of fibrin glue.
7. The method of claim 1 , wherein said placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site is performed so as to withstand the dynamic fluid pressure of said vascular vessel.
8. The method of claim 7 , wherein said remodelable biomaterial is placed so as to partially or fully encircle the exterior of a vessel wall at the treatment site.
9. The method of claim 7 , wherein said remodelable biomaterial is sutured or secured to the external circumference of the target vessel overlaying the treatment site.
10. The method of claim 7 , wherein opposite ends of said remodelable biomaterial touch or overlap each other.
11. The method of claim 1 , wherein said placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site is performed so as to increase the burst strength of said vascular vessel.
12. The method of claim 11 , wherein opposite ends of said remodelable biomaterial touch or overlap each other.
13. The method of claim 1 , wherein said aneurysm is not at a site of a vascular valve.
14. The method of claim 1 , wherein the aneurysm is a saccular, fusiform or dissecting aneurysm.
15. The method of claim 1 , wherein opposite ends of said remodelable biomaterial touch or overlap each other.
16. A method of treating a vascular vessel of a patient, the method comprising:
accessing a treatment site proximate to a defect in a vascular vessel;
placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site; and
wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation as a result of remodeling so as to modify the shape of and support the vessel wall at the treatment site.
17. The method of claim 16 , wherein opposite ends of said remodelable biomaterial touch and overlap each other with a slot and tab configuration.
18. A method of treating a vascular vessel of a patient, the method comprising:
accessing a treatment site proximate to a defect in a vascular vessel;
placing a remodelable biomaterial in contact with an exterior of a vessel wall at the treatment site; and
wherein said defect is an aneurysm or distention of the vessel wall, and wherein the remodelable biomaterial is effective to shrink after implantation so as to modify the shape of and support the vessel wall at the treatment site, and wherein said remodelable biomaterial is a multilaminate remodelable biomaterial.