IP Library › Patent Application 14172360
Patent Application
App. No. 14/172,360

METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
14/172,360
Abstract

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

Claims (5)

1 - 375 . (canceled)

376 . A cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker,

wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence.

377 . A method for targeting maytansinoids to a selected cell population in vivo, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population,

wherein the cell-binding agent is an antibody, a single chain antibody or an antibody fragment that specifically binds to a target cell, wherein at least a constant region of the antibody, single chain antibody or antibody fragment comprises a human antibody sequence.