Method of modulating the activity of functional immune molecules
View Patent ↗The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
1. An antibody composition comprising antibody molecules having complex-type and/or hybrid-type N-glycoside-linked sugar chain in a Fc region, wherein all of the antibody molecules have two N-glycoside-linked sugar chains in which fucose is not bound (F 0 ).
2. The antibody composition according to claim 1 , wherein the antibody comprises N-glycoside-linked sugar chains in which at least one N-acetylglucosamine is bound to a mannose at the non-reducing end of the following structure:
3. The antibody composition according to claim 1 , wherein the antibody comprises the complex-type N-glycoside-linked sugar chains in which two N-acetylglucosamine are respectively bound to two mannoses at the non-reducing end of the following structure;
4. The antibody composition according to claim 1 , wherein the antibody has an increased antibody dependent cellular cytotoxicity (ADCC).
5. The antibody composition according to claim 1 , wherein the antibody is a human antibody, a humanized antibody, a chimeric antibody or a human CDR-grafted antibody.
6. The antibody composition according to claim 1 , wherein the antibody is an IgG class antibody.