IP Library › Granted Patent US 9,045,537
Granted Patent B2
US 9,045,537 · App. 14/173,613 · Granted Jun 2, 2015

Antibodies specific to IL-17A and IL-17F

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Quick Facts
Patent No.
US 9,045,537
App. No.
14/173,613
Granted
Jun 2, 2015
Kind
B2
Abstract

The present invention relates neutralizing epitopes of IL-17A and IL-17F and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.

Claims (5)

1. A monoclonal antibody that specifically binds an epitope of human IL-17F, wherein the epitope comprises residues GLN71, CYS72, ILE86, ASN89, SER90 and VAL128 of SEQ ID NO:22 and wherein the monoclonal antibody additionally binds IL-17A.

2. The antibody of claim 1 , wherein the epitope comprises residues GLN71, CYS72, ASN74, LEU75, ILE86, ASN89, SER90, PRO92, VAL128, HIS131 and GLN133 of SEQ ID NO:22.

3. The antibody of claim 1 , which has binding affinity for human IL-17A of less than 500 pM.

4. The antibody of claim 1 , which has binding affinity for human IL-17A of less than 100 pM.

5. A composition comprising the antibody of claim 1 and a pharmaceutically acceptable excipient.

Assignments (2)
CONFIRMATORY ASSIGNMENT Recorded Jun 10, 2016
From: UCB PHARMA, S.A.
To: UCB BIOPHARMA SPRL
Reel/Frame 038953/0312 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 4, 2014
From: CESKA, THOMAS ALLEN; HENRY, ALISATAIR JAMES; SHI, JIYE
To: UCB PHARMA SA
Reel/Frame 032342/0908 →