IP Library › Granted Patent US 9,278,911
Granted Patent B2
US 9,278,911 · App. 14/176,923 · Granted Mar 8, 2016

4-dedimethylamino tetracycline compounds

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,278,911
App. No.
14/176,923
Granted
Mar 8, 2016
Kind
B2
Abstract

The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Claims (16)

1. A method for ameliorating rheumatoid arthritis in a subject in need thereof, the method comprising administering to said subject an effective amount of a tetracycline compound of the following structural formula:

or a pharmaceutically acceptable salt thereof, such that said rheumatoid arthritis in said subject is ameliorated.

2. The method of claim 1 , wherein said subject is a human.

3. The method of claim 1 , wherein said tetracycline compound is of the following structural formula:

4. The method of claim 1 , wherein said tetracycline compound is of the following structural formula:

5. The method of claim 1 , wherein said tetracycline compound is of the following structural formula:

6. The method of claim 1 , wherein said tetracycline compound is of the following structural formula:

7. The method of claim 1 , wherein said tetracycline compound is of the following structural formula:

8. A method for ameliorating rheumatoid arthritis in a subject in need thereof, the method comprising administering to said subject an effective amount of a pharmaceutical composition comprising a tetracycline compound of the following structural formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, such that said rheumatoid arthritis in said subject is ameliorated.

9. The method of claim 8 , wherein said subject is a human.

10. The method of claim 8 , wherein said tetracycline compound is of the following structural formula:

11. The method of claim 8 , wherein said tetracycline compound is of the following structural formula:

12. The method of claim 8 , wherein said tetracycline compound is of the following structural formula:

13. The method of claim 8 , wherein said tetracycline compound is of the following structural formula:

14. The method of claim 8 , wherein said tetracycline compound is of the following structural formula:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2015
From: NELSON, MARK L.; OHEMENG, KWASI
To: PARATEK PHARMACEUTICALS, INC.
Reel/Frame 036573/0903 →