Cancer cell targeting using nanoparticles
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
1. A pharmaceutical composition comprising:
a pharmaceutically acceptable carrier; and
a plurality of nanoparticles, wherein the nanoparticles each comprise:
a chemotherapeutic agent;
a diblock copolymer of poly (ethylene)glycol and polylactic acid; and
a ligand conjugate represented by:
wherein:
R 1 and R 3 are alkyl groups;
R 2 is an ester or amide linkage;
X/(X+Y) is 0.5 to 1;
Y/(X+Y) is 0 to 0.5;
X+Y is 20 to 1720; and
Z is 25 to 455.
2. The pharmaceutical composition of claim 1 , wherein Y is 0.
3. The pharmaceutical composition of claim 2 , wherein R 2 is an ester linkage.
4. The pharmaceutical composition of claim 1 , wherein the chemotherapeutic agent is docetaxel.