Iron (III) citrate, substantially free of beta-iron hydroxide oxide
View Patent ↗This invention provides a method for producing high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, and medical uses thereof.
1. A method for producing iron(III) citrate comprising:
a step of forming an iron-containing precipitate comprising bringing ferric chloride into contact with sodium hydroxide in an aqueous medium for a duration of two hours or less at a liquid temperature of 0° C. to 10° C. to form an iron-containing precipitate;
a step of generating an aqueous solution of iron(III) citrate comprising bringing citric acid into contact with the iron-containing precipitate in an aqueous medium and generating an aqueous solution of iron(III) citrate via heating; and
a step of precipitating iron(III) citrate comprising bringing the aqueous solution of iron(III) citrate into contact with an organic solvent to precipitate the iron(III) citrate.
2. The method according to claim 1 , wherein the step of generating an aqueous solution of iron(III) citrate comprises bringing citric acid into contact with the iron-containing precipitate at a liquid temperature of 60° C. to 100° C.
3. The method according to claim 1 , wherein the iron-containing precipitate is ferrihydride.
4. The method according to claim 1 , wherein the duration during which ferric chloride is in contact with sodium hydroxide is one hour or less.
5. The method according to claim 1 , wherein the duration during which ferric chloride is in contact with sodium hydroxide is 30 minutes or less.
6. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of lower than 10° C.
7. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 3.5° C. to 8° C.
8. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.6° C. to 7.5° C.
9. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.6° C. to 7.6° C.
10. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 0° C. to 7.3° C.
11. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.3° C. to 8.3° C.
12. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.5° C. to 8.4° C.
13. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.9° C. to 8.0° C.
14. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 1.4° C. to 8.3° C.
15. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 2.2° C. to 9.1° C.
16. The method according to claim 1 , wherein the step of forming an iron-containing precipitate comprises bringing ferric chloride into contact with sodium hydroxide in an aqueous medium at a liquid temperature of 3.0° C. to 5.3° C.