Therapeutic compounds and uses thereof
Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases are also provided.
1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is hydrogen or optionally substituted C 1-6 alkyl;
R 2 is optionally substituted heterocyclyl having 1 or 2 heteroatoms;
X is a bond, —O—, or —C(═O)—;
Y is N;
R 3 is optionally substituted heteroaryl; and
n is 0, 1, 2, 3, or 4.
2. A compound of claim 1 , wherein the compound is of Formula (II):
or a pharmaceutically acceptable salt thereof, wherein:
each instance of R 4 is independently selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, F, CI, Br, I, CN, OH, and alkoxy;
R 5 is hydrogen or a nitrogen protecting group; and
m is 0, 1, 2, 3, 4, or 5.
3. The compound of claim 1 , wherein the compound is of Formula (II-a):
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is of Formula (II-b):
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein the compound is of Formula (II-b1):
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound is of Formula (II-b2):
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound is of Formula (II-b3):
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein the compound is of Formula (II-b4):
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the compound is of Formula (II-c):
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is of Formula (II-d):
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound is of Formula (II-d1):
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 , wherein the compound is of Formula (II-d2):
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein the compound is of Formula (II-d3):
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein the compound is of Formula (II-d4):
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein the compound is of Formula (III):
or a pharmaceutically acceptable salt thereof, wherein:
each instance of R 4 is independently selected from the group consisting of hydrogen, optionally substituted C 1-6 alkyl, F, Cl, Br, I, CN, OH, and alkoxy;
R 5 is hydrogen or nitrogen protecting group; and
m is 0, 1, 2, 3, or 4.
16. The compound of claim 1 , wherein the compound is of Formula (III-a):
or a pharmaceutically acceptable salt thereat.
17. The compound of claim 1 , wherein the compound is of Formula (III-b):
or a pharmaceutically acceptable salt thereof.
18. The compound of claim 1 , wherein the compound is of Formula (III-b1):
or a pharmaceutically acceptable salt thereof.
19. The compound of claim 1 , wherein the compound is of Formula (III-b2):
or a pharmaceutically acceptable salt thereof.
20. The compound of claim 1 , wherein the compound is of Formula (III-b3).
or a pharmaceutically acceptable salt thereof.
21. The compound of claim 1 , wherein the compound is of Formula (III-b4):
or a pharmaceutically acceptable salt thereof.
22. The compound of claim 1 , wherein the compound is of Formula (III-c):
or a pharmaceutically acceptable salt thereof.
23. The compound of claim 1 , wherein the compound is of Formula (III-d):
or a pharmaceutically acceptable salt thereof.
24. The compound of claim 1 , wherein the compound is of Formula (III-d1):
or a pharmaceutically acceptable salt thereof.
25. The compound of claim 1 , wherein the compound is of Formula (III-d2):
or a pharmaceutically acceptable salt thereof.
26. The compound of claim 1 , wherein the compound is of Formula (III-d3):
or a pharmaceutically acceptable salt thereof.
27. The compound of claim 1 , wherein the compound is of Formula (III-d4):
or a pharmaceutically acceptable salt thereof.
28. The compound of claim 2 , wherein R 5 is hydrogen.
29. The compound of claim 1 , wherein R 2 is
wherein each instance of p, q, s, and t is independently 0, 1, 2, 3, or 4.
30. The compound of claim 29 , wherein R 2 is
31. The compound of claim 29 , wherein R 2 is
32. The compound of claim 29 , wherein R 2 is
33. The compound of claim 1 having one of the following structures:
34. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
35. A compound represented by a formula:
or a pharmaceutically acceptable salt thereof.