ANTIMICROBIAL THERMOPLASTIC POLYMER COMPOSITIONS
Disclosed herein are methods and compositions of thermoplastic compositions with antimicrobial properties. The resulting compositions, comprising one or more thermoplastic polymers, a zinc additive component, and an acid stabilizer component, can be used in the manufacture of articles requiring antimicrobial protection while still retaining the advantageous physical properties of thermoplastic compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
1 . A thermoplastic composition comprising
a. a thermoplastic polymer component comprising a polycarbonate, polyalkylene terephthalate, polypropylene (PP), polyphenylene oxide (PPO), polyetherimide (PEI), or a combination thereof;
b. a zinc additive component; and
c. an acid stabilizer component.
2 . The thermoplastic composition of claim 1 , comprising
a. from greater than 0 wt % to less than 100 wt % of a thermoplastic polymer component comprising a polycarbonate, polyalkylene terephthalate, polypropylene (PP), polyphenylene oxide (PPO), polyetherimide (PEI), or a combination thereof;
b. from greater than 0 wt % to about 10 wt % of a zinc additive component; and
c. from greater than 0 wt % to about 5 wt % of an acid stabilizer component.
3 . The thermoplastic composition of claim 1 , wherein the thermoplastic polymer component comprises at least one polycarbonate.
4 . The thermoplastic composition of claim 1 , wherein the thermoplastic polymer component is present in an amount in the range of from greater than 0 to 99 wt % relative to the total weight of the composition.
5 . The thermoplastic composition of claim 1 , wherein the thermoplastic polymer is present in an amount in the range of from greater than 0 to 95 wt % relative to the total weight of the composition.
6 . The thermoplastic composition of claim 1 , wherein the zinc additive component comprises zinc, zinc oxide, zinc acetate, zinc stearate, zinc carbonate, zinc nitrate, or a salt thereof, or a combination thereof.
7 . The thermoplastic composition of claim 1 , wherein the zinc additive component is present in the composition in an amount in the range of from greater than 0 to about 5 wt % relative to the total weight of the composition.
8 . The thermoplastic composition of claim 1 , wherein the acid stabilizer comprises phosphorous acid, phosphoric acid, mono zinc phosphate, mono sodium phosphate, or sodium acid pyrophosphate, or a combination thereof.
9 . The thermoplastic composition of claim 8 , wherein the acid stabilizer component is phosphorous acid.
10 . The thermoplastic composition of claim 1 , wherein the acid stabilizer component is present in the composition in an amount in the range of from greater than 0 to about 5 wt % relative to the total weight of the composition.
11 . The thermoplastic composition of claim 1 , further comprising an additive selected from thermal stabilizer, UV stabilizer, primary anti-oxidant, secondary anti-oxidant, mold release agent, lubricant, flame retardant agent, smoke suppressor agent, buffer, acid scavenger, hydrolytic stabilizer, quencher, pigment, and combinations of two or more of the foregoing.
12 . The thermoplastic composition according to claim 1 , wherein the thermoplastic composition exhibits antimicrobial properties against at least one microorganism.
13 . The thermoplastic composition of claim 12 , wherein the microorganism comprises staphylococcus aureus , methicillin-sensitive staphylococcus aureus (MSSA), or methicillin-resistant staphylococcus aureus (MRSA), or a combination thereof.
14 . The thermoplastic composition according to claim 1 , wherein a molded part formed from the thermoplastic composition exhibits antimicrobial properties against at least one microorganism.
15 . The thermoplastic composition of claim 12 , wherein the antimicrobial properties comprise microbiostatic activity, bacteriostatic activity, fungistatic activity, or a combination thereof.
16 . The thermoplastic composition of claim 1 , wherein a molded part formed from the thermoplastic composition exhibits a microorganism logarithmic reduction (log R) of at least 1.0 as determined according to JIS Z 2801.
17 . The thermoplastic composition of claim 1 , wherein a molded part formed from the thermoplastic composition exhibits a greater microorganism logarithmic reduction (log R) as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
18 . The thermoplastic composition of claim 1 , wherein after a 24 hour incubation, a molded part formed from the thermoplastic composition exhibits a lower microorganism colony forming unit (CFU) value as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
19 . A thermoplastic composition, comprising
a. from greater than 0 wt % to about 99 wt % of a thermoplastic polymer component comprising at least one polycarbonate;
b. from greater than 0 wt % to about 10 wt % of a zinc additive component comprising zinc, zinc oxide, zinc acetate, zinc stearate, zinc carbonate, zinc nitrate, or a salt thereof, or a combination thereof; and
c. from greater than 0 wt % to about 10 wt % of an acid stabilizer component comprising phosphorous acid, phosphoric acid, mono zinc phosphate, mono sodium phosphate, or sodium acid pyrophosphate, or a combination thereof;
wherein a molded part formed from the thermoplastic composition exhibits greater antimicrobial activity compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
20 . The thermoplastic composition of claim 19 , wherein a molded part formed from the thermoplastic composition exhibits greater bacteriostatic activity compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
21 . The thermoplastic composition of claim 19 , wherein a molded part formed from the thermoplastic composition exhibits a microorganism logarithmic reduction (log R) of at least 1.0 as determined according to JIS Z 2801.
22 . The thermoplastic composition of claim 19 , wherein a molded part formed from the thermoplastic composition exhibits a greater microorganism logarithmic reduction (log R) as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
23 . The thermoplastic composition of claim 19 , wherein after a 24 hour incubation, a molded part formed from the thermoplastic composition exhibits a lower microorganism colony forming unit (CFU) value as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
24 . An article of manufacture comprising the thermoplastic composition according to claim 1 .
25 . The article of claim 24 , wherein the article is a medical device, surgical device, imaging device, monitoring device, blood care device, drug delivery device, interior trim, window, floor, cover, wall panel, door, enclosure, housing, panel, lighting switch, bedding part, furniture part, culinary device, food preparation device, food storage device, or food delivery device, or a combination thereof.
26 . A method for forming an antimicrobial thermoplastic blend comprising:
a. combining:
i. a thermoplastic polymer component comprising a polycarbonate, polyalkylene terephthalate, polypropylene (PP), polyphenylene oxide (PPO), polyetherimide (PEI), or a combination thereof;
ii. a zinc additive component; and
iii. an acid stabilizer component.
27 . The method of claim 26 , wherein the zinc additive component comprises zinc, zinc oxide, zinc acetate, zinc stearate, zinc carbonate, zinc nitrate, or a salt thereof, or a combination thereof.
28 . The method of claim 26 , wherein the acid stabilizer component comprises phosphorous acid, phosphoric acid, mono zinc phosphate, mono sodium phosphate, or sodium acid pyrophosphate, or a combination thereof.
29 . The method of claim 26 , wherein a molded part formed from the thermoplastic composition exhibits greater antimicrobial activity compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
30 . The method of claim 26 , wherein a molded part formed from the thermoplastic composition exhibits a microorganism logarithmic reduction (log R) of at least 1.0 as determined according to JIS Z 2801.
31 . The method of claim 26 , wherein a molded part formed from the thermoplastic composition exhibits a greater microorganism logarithmic reduction (log R) as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.
32 . The method of claim 26 , wherein after a 24 hour incubation, a molded part formed from the thermoplastic composition exhibits a lower microorganism colony forming unit (CFU) value as determined according to JIS Z 2801, compared to a molded part formed from an identical reference composition comprising the same thermoplastic component, and the same weight percentage of the same acid stabilizer component, but in the absence of the zinc additive component.