IP Library › Granted Patent US 9,545,457
Granted Patent B2
US 9,545,457 · App. 14/188,598 · Granted Jan 17, 2017

Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

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Quick Facts
Patent No.
US 9,545,457
App. No.
14/188,598
Granted
Jan 17, 2017
Kind
B2
Abstract

The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.

Claims (8)

1. A method comprising

using an ultrasound contrast agent to enhance contrast in an echocardiographic ultrasound image of a subject, wherein the ultrasound contrast agent comprises

1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL;

sodium chloride;

glycerin, present in an amount of about 0.1 mL/mL;

propylene glycol, present in an amount of about 0.1 mL/mL;

water, and

perfluoropropane.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Jun 27, 2019
From: JPMORGAN CHASE BANK, N.A.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 049623/0123 →
NOTICE OF SUCCESSION OF AGENCY Recorded Mar 30, 2017
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 042115/0769 →
SECURITY AGREEMENT Recorded Jun 30, 2015
From: LANTHEUS MEDICAL IMAGING, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 036013/0516 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2014
From: HUI, POH K.; BISHOP, JOHN E.; MADRIGAL, ELEODORO S.
To: DUPONT PHARMACEUTICALS COMPANY
Reel/Frame 032511/0503 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2014
From: BRISTOL-MYERS SQUIBB PHARMA COMPANY
To: ACP LANTERN ACQUISITION, INC.
Reel/Frame 032511/0546 →
CHANGE OF NAME Recorded Mar 24, 2014
From: DUPONT PHARMACEUTICAL COMPANY
To: BRISTOL-MYERS SQUIBB PHARMA COMPANY
Reel/Frame 032513/0583 →
MERGER Recorded Mar 24, 2014
From: ACP LANTERN ACQUISITION, INC.
To: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
Reel/Frame 032513/0615 →
CHANGE OF NAME Recorded Mar 24, 2014
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 032513/0620 →