IP Library Granted Patent US 9,821,071
Granted Patent B2
US 9,821,071 · App. 14/190,928 · Granted Nov 21, 2017

Oligosaccharide conjugates for targeting bacteria and uses related thereto

Inventors: Niren Murthy (Berkeley, CA); Eric Seth Gilbert (Atlanta, GA); Xinghai Ning (Athens, GA); Mark Goodman (Atlanta, GA); Bryan Stubblefield (Atlanta, GA)
Assignees: Emory University; Georgia Tech Research Corporation; Georgia State University Research Foundation, Inc.
A61K47/4823A61K31/496A61K45/06A61K49/0021A61K49/0032A61K49/0054A61K51/06A61K51/065C08B31/00C08L3/04
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Quick Facts
Patent No.
US 9,821,071
App. No.
14/190,928
Granted
Nov 21, 2017
Kind
B2
Abstract

This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Claims (4)

1. A composition comprising a positron-emitting radionuclide conjugated to maltodextrin.

2. The composition of claim 1 , wherein the positron-emitting radionuclide is selected from carbon-11, nitrogen-13, oxygen-15, fluorine-18, rubidium-82, and strontium-82.

3. The composition of claim 1 , wherein the maltodextrin has greater than 2 glucose oligomers.

4. The composition of claim 1 , wherein the composition is

Assignments (4)
CONFIRMATORY LICENSE Recorded Mar 16, 2018
From: GEORGIA INSTITUTE OF TECHNOLOGY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 045618/0937 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2014
From: MURTHY, NIREN; NING, XINGHAI
To: GEORGIA TECH RESEARCH CORPORATION
Reel/Frame 033209/0622 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2014
From: GOODMAN, MARK
To: EMORY UNIVERSITY
Reel/Frame 033192/0448 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2014
From: GILBERT, ERIC SETH; STUBBLEFIELD, BRYAN
To: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Reel/Frame 033192/0512 →
Continuity (3)
Continuation 13979382
Provisional Application 61432668 · Jan 14, 2011
Related Publication 20140219917A1 · Aug 7, 2014