Bio-available N-acetyl creatine species and compositions thereof
View Patent ↗Creatine derivatives and compositions containing a bioactive form of creatine. The new chemical entity comprises an acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species with enhanced solubility and bioavailability. Also provided by this invention are various methods for providing several beneficial effects that comprise administering compositions comprising N-acetyl creatine, N-acyl creatines, N,N-diacyl creatines or any N-acetyl creatine species to a mammalian subject, either chronically or acutely.
1. A composition for delivering bio-available creatine comprising:
an N-acetyl creatine species;
a non-aqueous solvent;
a preservative;
a physical stabilizing ingredient;
one or more surfactants;
wherein the N-acetyl creatine species comprises a N-Acyl creatyl amino acid dipeptide.
2. The composition of claim 1 further comprising one or more adjuvants selected from the group consisting of nucleotide species, peptides, protein isolates, lipids, starches, carbohydrates, polyols, minerals, electrolytes, amino trace elements, colorings, flavors, artificial sweeteners, anti-oxidants, vitamins and vitamin-like isoprenoids.
3. The composition of claim 2 wherein the composition further comprises water and the composition is an aqueous solution.
4. The composition of claim 1 wherein the composition further comprises a liquid fill material comprising:
a lipophilic solvent;
a hydrophilic non-aqueous vehicle;
1% to about 5% of water;
a preservative;
a physical stabilizing ingredient; and,
one or more surfactants;
wherein the composition is provided in the form of a capsule.
5. The composition of claim 1 further comprising one or more protein isolates.
6. The composition of claim 5 further comprising one or more adjuvants selected from the group consisting of nucleotide species, peptides, lipids, starches, carbohydrates, polyols, minerals, electrolytes, amino trace elements, colorings, flavors, artificial sweeteners, anti-oxidants, vitamins and vitamin-like isoprenoids.
7. A composition for delivering bio-available creatine comprising:
an N-acetyl creatine species;
a suitable non-aqueous solvent;
a preservative;
a polymer for imparting consistency; and,
a physical stabilizing ingredient;
wherein the composition is substantially stable at room temperature, stable at 104° Fahrenheit, and stable at 39° Fahrenheit; and,
wherein the N-acetyl creatine species comprises N,N-Diacyl creatine.
8. The composition of claim 7 further comprising one or more adjuvants selected from the group consisting of nucleotide species, peptides, lipids, starches, carbohydrates, polyols, minerals, electrolytes, amino trace elements, colorings, flavors, artificial sweeteners, anti-oxidants, vitamins and vitamin-like isoprenoids.
9. The composition of claim 8 further comprising one or more penetrating enhancers and a moisturizer; wherein the composition has a gel consistency and may be topically applied to the skin as a gel.
10. The composition of claim 9 further comprising one or more penetrating enhancers and a moisturizer; wherein the composition is contained in the reservoir of a transdermal patch delivery system comprising the reservoir, a line, an adhesive and a backing.
11. The composition of claim 2 further comprising one or more natural products selected from the group consisting of dried milk products, dried soy products, dried citrus fruit juices, dried non-citrus fruit juices, and dried vegetable juices.
12. A composition for delivering bio-available creatine comprising:
an N-acetyl creatine species;
a non-aqueous solvent;
a preservative;
a physical stabilizing ingredient;
one or more surfactants;
wherein the N-Acetyl creatine species comprises a N-Acyl creatyl dipeptide aliphatic ester.