Organ jacket and methods of use
An organ jacket fabricated from human birth tissue comprising at least one cross-linked amniotic membrane, or at least one cross-linked chorionic membrane, or at least one amniotic membrane, or at least one chorionic membrane, or any combination thereof. Methods of processing a membrane to form an organ jacket and methods of preventing graft rejection in solid organ transplantation and methods of reducing the incidence of acute and chronic rejection episodes after solid organ transplantation are also provided.
1. A method of preventing graft rejection in a recipient of a transplanted solid organ utilizing a resorbable organ jacket, comprising the steps of:
providing the resorbable organ jacket comprising:
at least one amniotic membrane, or
at least one chorionic membrane, or
any combination thereof;
the method comprising the step of:
applying the resorbable organ jacket to an external surface of the solid organ so as to envelope the entire organ immediately before transplant into the recipient,
wherein the at least one membrane is treated with at least one alcohol composition comprising from about 90% to about 100% ethanol, and
wherein the organ jacket is fully resorbable by the organ after application.
2. The method of claim 1 , wherein the solid organ is selected from the group consisting of heart, lung, liver, kidney, pancreas, intestine, endocrine gland or stomach.
3. The method of claim 1 , wherein the resorbable organ jacket includes a surface defining at least one opening for the solid organ's vasculature.
4. A method of reducing the incidence of acute or chronic rejection episodes in a recipient following a solid organ transplant utilizing a resorbable organ jacket, comprising the steps of:
providing the resorbable organ jacket comprising:
at least one amniotic membrane, or
at least one chorionic membrane, or
any combination thereof;
the method comprising the step of:
applying the resorbable organ jacket to an external surface of the solid organ so as to envelope the entire organ immediately before transplant into the recipient,
wherein the at least one membrane is treated with at least one alcohol composition comprising from about 90% to about 100% ethanol, and
wherein the organ jacket is fully resorbable by the organ after application.
5. The method of claim 4 , wherein the solid organ is selected from the group consisting of heart, lung, liver, kidney, pancreas, intestine, endocrine gland or stomach.
6. The method of claim 4 , wherein the resorbable organ jacket includes a surface defining at least one opening for the solid organ's vasculature.