Portable water quality instrument
A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.
1. A hand-held microfluidic testing device comprising:
a) a housing, wherein said housing comprises a cartridge receiving port;
b) a cartridge, wherein said cartridge comprises
i) a sample channel, wherein said sample channel comprises a first sample channel region and a second sample channel region, wherein a cross-section of said first sample channel region is smaller than a cross-section of said second sample channel region;
ii) a detection region comprising a first detection region and a second detection region, wherein a cross-section of said first detection region is larger than a cross-section of said second detection region and said second sample channel region is connected to said first detection region;
iii) Raman-scattering nanoparticles wherein said Raman-scattering nanoparticles are larger than said cross-section of said first sample channel region and larger than said cross-section of said second detection region, wherein said Raman-scattering nanoparticles are disposed to collect in said first detection region to form a region of densely packed said Raman-scattering nanoparticles; and,
c) an optical detection system in said housing, wherein said optical detection system is capable of providing an illuminating electric field, wherein said illuminating electric field is capable of being used for Raman spectroscopy with said Raman-scattering nanoparticles to analyze said sample under test input to said cartridge.
2. The microfluidic testing device of claim 1 , wherein said Raman-scattering nanoparticles have a size in a range of 10 nm to 10 μm.
3. The microfluidic testing device of claim 1 , wherein said Raman-scattering nanoparticles move when subject to forces selected from the group consisting of electroosmosis, electrophoresis, fluid pressure, moveable wall pressure, undulary electroosmosis, undulary electrophoresis, undulary fluid pressure and undulary moveable wall pressure.
4. The microfluidic testing device of claim 1 , wherein said Raman-scattering nanoparticles are selected from the group consisting of gold particles, copper particles, silver particles, magnetic particles, particles having binding chemistry, and quantum dots.
5. The microfluidic testing device of claim 1 , wherein said second detection region comprises a sieve structure having openings smaller than said Raman-scattering nanoparticles.
6. The microfluidic testing device of claim 1 , wherein said detection region comprises flexible material, wherein said flexible material is operably disposed to form said first sample channel region and said second detection channel region.
7. The microfluidic testing device of claim 1 comprising an input channel disposed to input said Raman-scattering nanoparticles into said second sample channel region.