IP Library › Patent Application 14198559
Patent Application
App. No. 14/198,559

TEC FAMILY KINASE INHIBITOR ADJUVANT THERAPY

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Patent No.
US None
App. No.
14/198,559
Abstract

Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy, vaccination and treatment of immune disorders and pathogenic infections.

Claims (6)

1 .- 33 . (canceled)

34 . A method for treating a patient having a relapsed or refractory chronic lymphocytic leukemia, comprising administering to the patient a Btk inhibitor and a Bcl-2 inhibitor.

35 . The method of claim 34 wherein the Btk inhibitor is ibrutinib.

36 . The method of claim 35 wherein ibrutinib is administered at a dosage of about 40 mg/day to about 1000 mg/day.

37 . The method of claim 34 wherein the patient has deletion in 17p.

38 . The method of claim 37 wherein the deletion in 17p is assessed by a biomarker screen.

Assignments (10)
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF ASSIGNOR PREVIOUSLY RECORDED AT REEL: 038285 FRAME: 0267. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Sep 7, 2017
From: OHIO STATE INNOVATION FOUNDATION
To: PHARMACYCLICS LLC
Reel/Frame 043779/0028 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 038029 FRAME: 0576. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Sep 7, 2017
From: BYRD, JOHN C.; MUTHUSAMY, NATARAJAN; JOHNSON, AMY JO; DUBOVSKY, JASON A.
To: OHIO STATE INNOVATION FOUNDATION
Reel/Frame 043779/0095 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0368. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME. Recorded May 18, 2016
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 038742/0371 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0359. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded May 17, 2016
From: OXFORD AMHERST CORPORATION; PHARMACYCLICS, INC.
To: PHARMACYCLICS, INC.
Reel/Frame 038742/0064 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2016
From: THE OHIO STATE UNIVERSITY
To: PHARMACYCLICS, INC.
Reel/Frame 038285/0267 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2016
From: MODY, TARAK D.
To: PHARMACYCLICS, INC.
Reel/Frame 038285/0194 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2016
From: BUGGY, JOSEPH J.; LOVE, RICHARD B.; CHANG, BETTY
To: PHARMACYCLICS, INC.
Reel/Frame 038285/0205 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 18, 2016
From: BYRD, JOHN C.; DUBOVSKY, JASON A.; MUTHUSAMY, NATARAJAN; JOHNSON, AMY JO
To: THE OHIO STATE UNIVERSITY
Reel/Frame 038029/0576 →
MERGER Recorded Jul 16, 2015
From: OXFORD AMHERST CORPORATION
To: PHARMACYCLICS, INC.
Reel/Frame 036126/0359 →
MERGER AND CHANGE OF NAME Recorded Jul 16, 2015
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 036126/0368 →