IP Library › Granted Patent US 10,005,790
Granted Patent B2
US 10,005,790 · App. 14/199,371 · Granted Jun 26, 2018

Process for the synthesis of substituted morphinans

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Quick Facts
Patent No.
US 10,005,790
App. No.
14/199,371
Granted
Jun 26, 2018
Kind
B2
Abstract

The present invention relates to compounds of formula I and a process for the synthesis: The invention further relates to a process for the synthesis of 3-carboxamide substituted morphinans where a 3-cyano substituted 6-oxo substituted morphinan is reacted with a 1,3-diol.

Claims (9)

1. A compound selected from Table 3:

TABLE 3

2. A compound of formula:

3. A compound of formula:

4. A compound of formula:

5. A compound of formula:

6. A compound of formula:

7. A compound of formula:

8. A compound of formula:

Assignments (4)
SECURITY INTEREST Recorded Feb 13, 2026
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 074858/0405 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (073213/0302) Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 074858/0429 →
SECURITY INTEREST Recorded Oct 23, 2025
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073213/0302 →
SECURITY INTEREST Recorded Mar 20, 2020
From: ALKERMES PHARMA IRELAND LIMITED
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 052914/0832 →