AEROSOL CONTAINER FOR FOAMABLE COMPOSITIONS
A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
1 . (canceled)
2 . An aerosol container comprising a pressurized product and an outlet capable of releasing the pressurized product as a foam;
wherein said pressurized product comprises a foamable composition comprising:
i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming;
ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight;
iii. a surface-active agent;
iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
v. water; and
vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
3 . The container of claim 2 , wherein the outlet comprises a valve.
4 . The container of claim 3 , wherein the valve comprises a stem with at least 1 aperture formed in said stem.
5 . The container of claim 4 , wherein the valve comprises a stem with 1 to 4 apertures formed in said stem.
6 . The container of claim 4 , wherein each said aperture formed in said stem has a diameter of about 0.2 mm to about 1 mm.
7 . The container of claim 4 , wherein each said aperture formed in said stem has a diameter of about 0.3 mm to about 0.8 mm.
8 . The container of claim 4 , wherein the sum of areas of all apertures in said stem is between about 0.01 mm2 and 1 mm2.
9 . The container of claim 4 , wherein the sum of areas of all apertures in said stem is between about 0.04 mm2 and 0.5 mm2.