Combination diffused and focused fiber optic for diagnosis and treatment of diseased cells
View Patent ↗A method of treating diseased cells including the steps of instilling an optical imaging agent to a tissue of a patient, accessing the tissue with a device comprising a fiber tip, emitting a first light from the fiber tip and photodynamically diagnosing abnormal cells, and emitting a second light from the fiber tip to treat the abnormal cells. The first light can be a first power blue light and the second light can be a second power blue light, where the first power blue light can be a lower power than the second power blue light.
1. A method of treatment, the method comprising the steps of:
delivering an optical imaging agent to a tissue;
accessing the tissue with a device comprising a sleeve with a lumen, an optical fiber in the lumen, and a fiber tip on the optical fiber;
moving the optical fiber relative to the lumen until a diffused area of the fiber tip is out of the lumen;
emitting a first light from a light source through the optical fiber and the at least one diffused area of the fiber tip to photodynamically identify a treatment area on the tissue;
moving the optical fiber relative to the lumen until at least a portion of the diffused area is in the lumen; and
emitting a second light from the light source through the optical fiber and a focused area of the fiber tip to treat the treatment area.
2. The method of claim 1 , wherein the first light is a first power blue light and the second light is a second power blue light.
3. The method of claim 2 , wherein the first power blue light is a lower power than the second power blue light.
4. The method of claim 1 , wherein the optical imaging agent comprises hexylaminolevulinate.
5. The method of claim 1 , wherein the treatment area comprises a bladder tissue.
6. The method of claim 5 , wherein the treatment area comprises at least one of cancerous cells and precancerous cells.
7. The method of claim 1 , wherein the least one focused area includes a depressed surface of the fiber tip and the at least one diffused area includes raised surface that surrounds the depressed surface.
8. The method of claim 7 , wherein the depressed surface is an end firing surface of the fiber tip and a portion of the raised surface is a side firing surface of the fiber tip.
9. A method of treatment, the method comprising the steps of:
delivering an optical imaging agent to a treatment region;
delivering a sleeve with a lumen to the treatment region;
delivering a distal tip of an optical fiber to the treatment region through the lumen;
moving a diffused area on the distal tip out of the lumen;
emitting a first light from the light source through the optical fiber and the diffused area of the distal tip;
photodynamically identifying a treatment area in the treatment region with the first light;
moving the diffused area into the lumen;
emitting a second light from the light source through the optical fiber and a focused area of the distal tip; and
treating the treatment area with the second light.
10. The method of claim 9 , wherein the first light has a first power and the second light has a second power.
11. The method of claim 10 , wherein the first power is lower than the second power.
12. The method of claim 9 , wherein the first light and the second light are blue light.
13. The method of claim 9 , wherein the optical imaging agent comprises hexylaminolevulinate.
14. The method of claim 9 , wherein the treatment region is a bladder and the treatment area comprises a bladder tissue.
15. The method of claim 9 , wherein the treatment area comprises at least one of cancerous cells and precancerous cells.
16. The method of claim 9 , wherein the focused area is a polished end firing surface of the distal tip and the diffused area is an unpolished side firing surface of the distal tip.
17. The method of claim 9 , wherein treating the treatment area comprises vaporizing a portion of the treatment area.
18. A method of treatment, the method comprising the steps of:
delivering an optical imaging agent to a treatment region;
delivering a sleeve with a lumen to the treatment region;
delivering a distal tip of an optical fiber to the treatment region through the lumen, the distal tip including a side firing surface and an end firing surface;
moving the optical fiber out of the lumen until the side firing surface is adjacent the treatment region;
emitting a first light from the light source through the optical fiber and at least one diffused area on the side firing surface;
photodynamically identifying a treatment area in the treatment region with the first light;
moving the optical fiber into the lumen until the end firing surface is aligned with the treatment area;
emitting a second light from the light source through the single optical fiber and at least one focused area on the end firing surface; and
vaporizing a portion of the treatment area with the second light.
19. The method of claim 1 , further comprising the steps of:
delivering a diagnostic signal from the optical fiber to the treatment area; and
reading a tissue signature from the diagnostic signal.
20. The method of claim 19 , further comprising the steps of:
delivering a diagnostic signal from the optical fiber to the treatment area; and
reading a tissue signature from the diagnostic signal.