Process for the preparation of a solid, orally administrable pharmaceutical composition
A process for the preparation of a solid, orally administrable pharmaceutical composition, comprising 5-chloro-N-({(5)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide comprising preparing granules in hydrophilized form using fluidized bed granulation for moist granulation, adding additives, compressing to form a tablet, and coating the tablet.
1. A process for the preparation of a solid, orally administrable pharmaceutical tablet comprising an active compound (I) that is 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide in hydrophilized form, comprising the following steps:
(a) preparing granules comprising the active compound (I) in hydrophilized form using fluidized bed granulation for moist granulation;
(b) adding at least one pharmaceutically suitable additive to the granules and compressing to form a tablet; and
(c) coating to form the pharmaceutical tablet.
2. The process according to claim 1 , wherein the resulting pharmaceutical tablet rapidly releases the active compound (I).