COMPOSITIONS FOR IMPROVING THE APPEARANCE AND/OR HEALTH OF TEETH
In various embodiments compositions are provided for the whitening, and/or brightening, and/or restoration of a tooth. In various embodiments the compositions, referred to herein as “dental care” compositions typically comprise a binding moiety that binds to calcium and/or to tooth enamel and/or to pellicle attached to an active agent. The active agent is selected to deliver a particular activity (e.g., whitening, remineralization, desensitization, brightening, etc.) to the tooth.
1 : A composition for the whitening, and/or brightening, and/or restoration of a tooth, said composition comprising:
a binding moiety that binds to calcium and/or to tooth enamel and/or to pellicle attached to an active agent selected from the group consisting of a white colorant, a bleach, an enzyme, an anti-plaque agent, a desensitization agent, a remineralization agent, or any combination thereof.
2 : The composition of claim 1 , wherein a plurality of binding moieties are attached to each active agent.
3 : The composition of claim 1 , wherein a plurality of active agents are attached to each binding moiety.
4 : The composition of claim 1 , wherein a single binding moiety is attached to a single active agent.
5 : The composition of claim 1 , wherein said binding moiety is selected from the group consisting of an enamel matrix proteins (EMP) or enamel-binding fragment thereof, an enamel or calcium binding peptide, and an enamel or calcium binding tannin.
6 - 7 . (canceled)
8 : The composition of claim 5 , wherein said binding moiety comprises an enamel and/or calcium binding peptide comprising one or more peptide domains said domain(s) comprising the sequence (X-Y-Z) n , wherein:
X is an amino acid selected from the group consisting of aspartic acid, glutamic acid, asparagine, alanine and glutamine or a conservative substitution thereof;
Y and Z are amino acids independently selected from alanine, serine, threonine, phosphoserine, and phosphothreonine, or conservative substitutions thereof; and n is a number from 1 to 100; and
wherein when more than one of said domains is present the domains can be the same or different; and wherein said calcium-binding peptide moiety binds calcium phosphate.
9 - 12 . (canceled)
13 : The composition of claim 8 , wherein Y and Z are the same amino acid.
14 : The composition of claim 13 , wherein Y and Z are both serine or a conservative substitution thereof or both phosphoserine or a conservative substitution thereof, or both threonine or a conservative substitution thereof, or both phosphothreonine or a conservative substitution thereof.
15 - 23 . (canceled)
24 : The composition of claim 8 , wherein X is aspartic acid or a conservative substitution thereof, or glutamic acid or a conservative substitution thereof.
25 - 33 . (canceled)
34 : The composition of claim 8 , wherein said peptide ranges in length from about 6 to about 60 amino acids.
35 . (canceled)
36 : The composition of claim 8 , wherein n ranges from about 3 up to about 12.
37 . (canceled)
38 : The composition of claim 8 , wherein the amino acid sequence of said peptide comprises a sequence selected from the group consisting of (DSS) 3 , (DSS) 4 , (DSS) 5 , (DSS) 6 , (DSS) 7 , (DSS) 8 , (DSS) 9 , and (DSS) 10 .
39 - 41 . (canceled)
42 : The composition of claim 8 , wherein said peptide is not phosphorylated.
43 - 47 . (canceled)
48 : The composition of claim 1 , wherein said active agent comprises a whitening agent and/or a colorant.
49 : The composition of claim 48 , wherein said whitening agent and/or colorant comprises a bleach or a peroxide.
50 . (canceled)
51 : The composition of claim 48 , wherein said whitening agent and/or colorant is selected from the group consisting of hydroxyapatite, zirconium silicate, titanium dioxide, titanium dioxide nanoparticles silica dioxide, and a white pigment or dye.
52 . (canceled)
53 : The composition claim 1 , wherein said active agent comprises an enzyme selected from the group consisting of an oxidase, a peroxidase, a protease, a lipase, glucosidase, an esterase, and a polysaccharide hydrolase.
54 . (canceled)
55 : The composition of claim 1 , wherein said active agent comprises an agent selected from the group consisting of an anti-plaque agent, a desensitization agent, and a remineralization agent.
56 - 65 . (canceled)
66 : The composition of claim 1 , wherein said active agent is attached to said binding moiety through a peptide linker.
67 - 72 . (canceled)
73 : An oral care formulation comprising an effective amount of the composition of claim 1 , wherein said formulation is selected from the group consisting of toothpaste, dental cream, gel, tooth powder, mouth wash, breath freshener, and dental floss.
74 - 77 . (canceled)
78 : A method of improving the health and/or appearance of a tooth, said method comprising contacting said tooth with an effective amount of a composition of claim 1 .
79 - 85 . (canceled)