COMPOSITIONS AND METHODS FOR REDUCING FOOD CRAVINGS

1 . A method of reducing food cravings, comprising:

identifying a food-craving subject; and

administering a first compound and a second compound to the subject in an amount that is effective to reduce food craving;

wherein the first compound is selected from an opioid antagonist and an anticonvulsant; and

wherein the second compound is an α-MSH activity enhancer.

2 . (canceled)

3 . The method of claim 1 , wherein the opioid antagonist is selected from alvimopan, norbinaltorphimine, nalmefene, naloxone, naltrexone, methylnaltrexone, nalorphine, and pharmaceutically acceptable salts, metabolites or prodrugs thereof.

4 . The method of claim 3 , wherein the opioid antagonist is selected from naltrexone and 6-13 naltrexol.

5 . (canceled)

6 . (canceled)

7 . (canceled)

8 . The method of claim 1 , wherein the α-MSH activity enhancer is bupropion.

9 . The method of claim 1 , wherein the anticonvulsant is selected from zonisamide, topiramate, nembutal, lorazepam, clonazepam, clorazepate, tiagabine, gabapentin, fosphenytoin, phenytoin, carbamazepine, valproate, felbamate, levetiracetam, oxcarbazepine, lamotrigine, methsuximide, and ethosuxmide, and pharmaceutically acceptable salts, metabolites or prodrugs thereof.

10 . The method of claim 9 , wherein the anticonvulsant is selected from zonisamide, a zonisamide metabolite and a zonisamide prodrug.

11 . The method of claim 1 , wherein the opioid antagonist is selected from naltrexone, a naltrexone prodrug and a naltrexone metabolite; and wherein the α-MSH activity enhancer is selected from bupropion, a bupropion prodrug and a bupropion metabolite.

12 . (canceled)

13 . (canceled)

14 . The method of claim 1 , wherein the anticonvulsant is selected from zonisamide, a zonisamide metabolite and a zonisamide prodrug; and wherein the α-MSH activity enhancer is selected from bupropion, a bupropion prodrug and a bupropion metabolite.

15 . (canceled)

16 . (canceled)

17 . (canceled)

18 . The method of claim 1 , wherein the first compound is administered to the subject prior to the second compound.

19 . The method of claim 1 , wherein the first compound and the second compound are combined in a single dosage form.

20 . (canceled)

21 . (canceled)

22 . The method of claim 1 , wherein the patient is overweight or obese.

23 . (canceled)

24 . (canceled)

25 . (canceled)

26 . The method of claim 1 , wherein the first compound and the second compound are administered to the subject in an amount that is effective to synergistically reduce food craving.

27 . A package comprising:

a first compound and a second compound in unit dosage form; and

written instructions advising the reader to administer the unit dosage form to the intended recipient to alleviate food craving;

wherein the first compound is selected from an opioid antagonist and an anticonvulsant; and

wherein the second compound is an α-MSH activity enhancer.

28 . The package of claim 27 , wherein the first compound and the second compound are combined in a single unit dosage form.

29 . The package of claim 27 , wherein the opioid antagonist is selected from naltrexone, a naltrexone prodrug and a naltrexone metabolite; and wherein the α-MSH activity enhancer is selected from bupropion, a bupropion prodrug and a bupropion metabolite.

30 . The package of claim 29 , wherein the unit dosage form is a controlled release form.

31 . The package of claim 30 , wherein the controlled release form is a sustained release form.

32 . The package of claim 27 , wherein the anticonvulsant is selected from zonisamide, a zonisamide prodrug and a zonisamide metabolite; and wherein the α-MSH activity enhancer is selected from bupropion, a bupropion prodrug and a bupropion metabolite.

33 . The package of claim 32 , wherein the unit dosage form is a controlled release form.

34 . The package of claim 33 , wherein the controlled release form is a sustained release form.