Rotatable fluid sample collection device
View Patent ↗A sample collection device for a fluid sample includes: a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; an air vent located in the vicinity of the second end and in fluid communication with the capillary channel; a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and features on opposing sides of the body to form an axis of rotation, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a sample manipulation device to bring the first end into position with the sample manipulation device.
1. A method for collecting a fluid sample comprising:
providing a working element which comprises:
a sample collection device for a fluid sample, the device comprising:
a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action;
an air vent located in the vicinity of the second end and in fluid communication with the capillary channel;
a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and
features on opposing sides of the body; and
a cartridge having a sample manipulation device, wherein the cartridge has features that correspond to features on the sample collection device to form an axis of rotation, about which the sample collection device rotates, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end about which the sample collection device rotates, and wherein the sample collection device is adapted to rotate about the axis of rotation to bring the first end into position with the sample manipulation device;
rotating the sample collection device to position the first end in a direction extending away from the cartridge;
bringing the first end into contact with the sample, whereby capillary action draws the sample into the channel and to the barrier;
rotating the sample collection device to position the first end into position with the sample manipulation device; and
applying air pressure to the air vent to force the sample across the barrier and into contact with the sample manipulation device.
2. A method as claimed in claim 1 , wherein the sample is an aqueous fluid sample.
3. A sample collection device as claimed in claim 2 , wherein the fluid is a bodily fluid.
4. A method of as claimed in claim 2 , wherein the sample is whole blood, serum, plasma or urine.
5. A method as claimed in claim 1 , wherein the step of bringing the first end into contact with the sample comprises bringing the first end into contact with a drop of blood on an animal.
6. A method as claimed in claim 5 , wherein the animal is a mammal.
7. A method as claimed in claim 6 , wherein the mammal is a human.
8. A method as claimed in claim 1 , wherein the step of bringing the first end into contact with the sample comprises bringing the first end into contact with a syringe containing blood from an animal.
9. A method as claimed in claim 1 , wherein the sample manipulation device includes a sample pre-manipulation portion comprising at least one filter in fluid communication with the first end of the capillary channel.
10. A method as claimed in claim 1 , wherein the sample manipulation device is an analytical chamber adapted to be in fluid communication with the first end of the capillary channel upon rotation of the sample collection device.
11. A method as claimed in claim 10 , wherein the analytical chamber is provided with an analytical reagent.
12. A method as claimed in claim 1 , wherein the body has a substantially rectangular shape, and wherein the first end is located at the first shorter side and the second end is located in the vicinity of the second shorter side.
13. A method as claimed in claim 1 , wherein the sample collection device is located at a first end of the cartridge housing.
14. A method as claimed in claim 13 , wherein a portion of the cartridge housing has a groove which contains the sample collection device.
15. A method as claimed in claim 14 , wherein the body has a substantially rectangular shape, and wherein the first end is located at the first shorter side and the second end is located in the vicinity of the second shorter side.
16. A method as claimed in claim 15 , wherein the features of the cartridge that form the axis of rotation are located in the portion of the housing that forms the groove or a recess in the groove, whereby the sample collection device rotates from a position where the first end extends away from the cartridge to a position where the first end is in contact with the sample manipulation device.