Factor H for transplantation
View Patent ↗The present invention provides a method for preventing or inhibiting allograft rejection by a recipient of that allograft by treating the recipient with a composition comprising Factor H (FH). The invention also encompasses methods in which the recipient is also administered one or more immunosuppressants in addition to the Factor H.
1. A method for inhibiting allograft rejection by a recipient of said allograft, said method comprising treating said recipient with a composition comprising Factor H (FH), sirolimus (Rapamycin) and FK506 (FK).
2. The method of claim 1 , wherein said FH is plasma-derived FH or recombinant FH.
3. The method of claim 1 , wherein said allograft rejection is an antibody mediated rejection or a combination of antibody and cell mediated rejection.
4. The method of claim 1 , wherein said inhibiting allograft rejection comprises prolonging allograft survival and/or function for a predetermined number of days.
5. The method of claim 1 , wherein said inhibiting allograft rejection comprises preventing or inhibiting an increase in levels of markers of allograft rejection.
6. The method of claim 1 , wherein said allograft rejection is acute antibody-mediated rejection.
7. The method of claim 5 , wherein said recipient is treated with the composition upon receipt of said allograft until said allograft functions normally.
8. The method of claim 6 , wherein normal function of said allograft is determined by recipient creatinine level and/or negative C4d biopsy testing.
9. The method of claim 1 , wherein said allograft rejection occurs 3-6 months after receipt of said allograft.
10. The method of claim 1 , wherein said allograft comprises an organ.
11. The method of claim 10 , wherein said organ is a whole organ.
12. The method of claim 11 , wherein said whole organ is a member selected from kidney, heart, liver, intestine, pancreas and lung.
13. The method of claim 1 , wherein said allograft comprises tissue.
14. The method of claim 1 , wherein said allograft is a member selected from a skin graft, a bone graft, a valve, and bone marrow.