IP Library Granted Patent US 10,449,501
Granted Patent B2
US 10,449,501 · App. 14/211,668 · Granted Oct 22, 2019

Evaporation-controlling container inserts

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Quick Facts
Patent No.
US 10,449,501
App. No.
14/211,668
Granted
Oct 22, 2019
Kind
B2
Abstract

An apparatus configured for mixing the contents of one or more fluid containers includes a fluid container support platform configured to hold one or more fluid containers. The fluid container support platform is configured to index the container to one or more specified locations and to be moved in an orbital path about an orbital center independently of the rotation about the central axis of rotation. The apparatus further includes an indexing drive system configured to effect indexing movement of the container support platform and a vortex drive system configured to effect powered orbital movement of the container support platform about the orbital center. An evaporation limiting insert placed within containers reduces exposure of the fluid contents of the container to atmospheric air, thereby reducing susceptibility of the fluid contents to evaporation.

Claims (31)

1. An evaporation-limiting insert for a container comprising a hollow tubular body configured to extend into a container from an opening of the container, wherein the tubular body comprises a retainer feature situated at an upper end portion of the tubular body, the retainer feature being configured to engage a portion of the container to secure the insert within the container, wherein the tubular body includes a plurality of holes extending through a wall of the tubular body, the holes permitting fluid movement through an interior space of the tubular body, and each of the holes being situated above a bottom edge of the tubular body, wherein a majority of the holes are situated below a midpoint of the tubular body.

2. The evaporation-limiting insert of claim 1 , wherein the tubular body has a length extending from the opening of the container to a bottom surface of an interior of the container, and wherein the bottom edge of the tubular body is configured to form one or more gaps situated between the bottom edge and the bottom surface of the interior of the container when the evaporation-limiting insert is fully inserted into the container.

3. The evaporation-limiting insert of claim 2 , wherein the bottom edge is an undulating surface such that one or more gaps are formed between the bottom edge and the bottom surface of the interior of the container when the evaporation-limiting insert is fully inserted into the container.

4. The evaporation-limiting insert of claim 2 , comprising one or more slots extending axially from the bottom edge to thereby form one or more of the gaps situated between the bottom edge and the bottom surface of the interior of the container when the evaporation-limiting insert is fully inserted into the container.

5. The evaporation-limiting insert of claim 1 , wherein the retainer feature comprises a detent configured to resiliently engage an inside surface of the container.

6. The evaporation-limiting insert of claim 1 , wherein the retainer feature comprises two or more resilient tabs formed at a top portion of the tubular body and configured to deflect inwardly when the insert is inserted into the container and to press resiliently against an inside surface of the container.

7. The evaporation-limiting insert of claim 6 , wherein the tabs are separated by slits extending lengthwise in a wall of the tubular body from a top edge thereof, wherein the length of each slit is longer than a neck of the container, so that each slit extends below the neck of the container when the evaporation-limiting insert is fully inserted into the container.

8. The evaporation-limiting insert of claim 1 , wherein the tubular body is substantially cylindrical and has a substantially constant diameter along its entire length.

9. The evaporation-limiting insert of claim 1 , wherein the tubular body is tapered such that an outside dimension of the tubular body progressively decreases moving from the upper end portion to a lower end portion of the tubular body.

10. A combination of a container having a fluid contained therein and the evaporation-limiting insert of claim 1 , wherein the container comprises,

an opening having an inside dimension generally conforming to the outside dimension of the upper end portion of the tubular body, with the upper end portion of the tubular body disposed within the opening and the retainer feature engaged with a portion of the container; and

a bottom surface,

wherein the surface of the fluid is disposed above a majority of the holes formed in the tubular body.

11. The combination of claim 10 , wherein the fluid comprises solid supports.

12. The combination of claim 11 , wherein the solid supports are magnetically-responsive particles or beads.

13. The combination of claim 10 , wherein the tubular body has a length extending from the opening of the container to the bottom surface of the interior of the container, and wherein the tubular body has a bottom edge forming one or more gaps between the bottom edge and the bottom surface of the interior of the container.

14. The combination of claim 13 , wherein the bottom edge is an undulating surface.

15. The combination of claim 13 , comprising one or more slots extending axially from the bottom edge.

16. The combination of claim 10 , wherein the retainer feature comprises a detent resiliently engaged with an inside surface of the container.

17. The combination of claim 10 , wherein the retainer feature comprises two or more resilient tabs formed at a top portion of the tubular body and pressing resiliently against an inside surface of the container.

18. The combination of claim 17 , wherein the tabs are separated by slits extending lengthwise in a wall of the tubular body from a top edge thereof, wherein the length of each slit is longer than a neck of the container, so that each slit extends below the neck of the container.

19. The combination of claim 10 , wherein the tubular body is substantially cylindrical and has a substantially constant diameter along its entire length.

20. The combination of claim 10 , wherein the tubular body is tapered such that an outside dimension of the tubular body progressively decreases moving from the upper end portion to a lower end portion of the tubular body.

21. The evaporation-limiting insert of claim 1 , wherein all of the holes are situated below the mid-point of the tubular body.

22. The combination of claim 10 , wherein all of the holes are situated below the mid-point of the tubular body.

23. The evaporation-limiting insert of claim 1 , wherein each group of axially-aligned holes comprises at least three holes.

24. The evaporation-limiting insert of claim 23 , wherein each group of axially-aligned holes comprises no more than six holes.

25. The combination of claim 10 , wherein each group of axially-aligned holes comprises at least three holes.

26. The combination of claim 25 , wherein each group of axially-aligned holes comprises no more than six holes.

27. The evaporation-limiting insert of claim 1 , wherein the holes are arranged in two groups aligned axially along diametrically-opposed sides of the tubular body.

28. The combination of claim 10 , wherein the holes are arranged in two groups aligned axially along diametrically-opposed sides of the tubular body.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 054089/0804 Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC; GEN-PROBE PRODESSE, INC.
Reel/Frame 075504/0575 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Oct 15, 2020
From: HOLOGIC, INC.; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 054089/0804 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 032753/0942 Recorded Jun 3, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035813/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2014
From: KNIGHT, BYRON J.
To: GEN-PROBE INCORPORATED
Reel/Frame 032958/0357 →
SECURITY INTEREST Recorded Apr 25, 2014
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK, USA
Reel/Frame 032753/0942 →