Method for treating glioblastomas and other tumors
View Patent ↗Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor radiation therapy on an astrocytoma in a subject. Also provided are methods of treating other solid tumor types, and tumor cell invasion, with guanylhydrazone compounds.
1. A method of treating an astrocytoma in a subject, wherein the subject is also being treated with ionizing radiotherapy for the astrocytoma, comprising administering to the subject an amount of a guanylhydrazone compound having the formula:
wherein in each case, n=1 or 2, and wherein when n=2, the two molecules are joined through R 3 ,
wherein each R 1 is, independently, chosen from —H or —CH 3 ,
and wherein R 3 is a C1-C10 hydrocarbyl, branched or unbranched, optionally substituted;
or having the formula:
wherein each R 4 is, independently, chosen from —H or —CH 3 ,
and wherein X═C2-C8 alkynyl, —CN 3 , or —C(O)NHR wherein R is a di-substituted aryl,
or is a pharmaceutically acceptable salt thereof, effective to treat an astrocytoma.
2. The method of claim 1 , wherein the astrocytoma is a glioblastoma.
3. The method of claim 2 , wherein glioblastoma is a glioblastoma multiforme.
4. The method of claim 1 , wherein the guanylhydrazone compound has the formula:
wherein n=1 or 2, and wherein when n=2, the two molecules are joined through R 3 ,
wherein each R 1 is, independently, chosen from —H or —CH 3 ,
and wherein R 3 is a C1-C10 hydrocarbyl, branched or unbranched, optionally substituted;
or wherein the guanylhydrazone compound has the formula:
wherein each R 4 is, independently, chosen from —H or —CH 3 ,
and wherein X═C2-C8 alkynyl, —CN 3 , or —C(O)NHR wherein R is a di-substituted aryl,
or is a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , wherein the guanylhydrazone compound has the structure:
or is a pharmaceutically acceptable salt thereof.
6. The method of claim 1 , wherein the guanylhydrazone compound is administered in a manner effective to deliver it to a brain of a subject.
7. The method of claim 1 , wherein the guanylhydrazone compound is administered into the brain of the subject.
8. The method of claim 1 , further comprising administering an anti-tumor therapy to the subject.
9. The method of claim 8 , wherein the anti-tumor therapy comprises brain tumor radiation therapy.