IP Library Granted Patent US 9,505,776
Granted Patent B2
US 9,505,776 · App. 14/212,745 · Granted Nov 29, 2016

Prodrugs of fumarates and their use in treating various diseases

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,505,776
App. No.
14/212,745
Granted
Nov 29, 2016
Kind
B2
Abstract

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Claims (12)

1. A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:

wherein:

R 1 is unsubstituted C 1 -C 6 alkyl;

L a is unsubstituted C 1 -C 6 alkyl linker; and

R 2 is H, unsubstituted C 1 -C 6 alkyl, unsubstituted C 2 -C 6 alkenyl, or unsubstituted C 2 -C 6 alkynyl.

2. The compound of claim 1 , wherein R 1 is methyl.

3. The compound of claim 1 , wherein L a is an unsubstituted C 1 -C 3 alkyl.

4. The compound of claim 1 , wherein L a is an unsubstituted C 2 alkyl.

5. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 3 alkyl.

6. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 2 alkyl.

7. The compound of claim 1 , wherein R 2 is methyl.

8. The compound of claim 1 , having structure:

Assignments (6)
SECURITY INTEREST Recorded Feb 13, 2026
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 074858/0405 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (073213/0302) Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 074858/0429 →
SECURITY INTEREST Recorded Oct 23, 2025
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073213/0302 →
SECURITY INTEREST Recorded Apr 4, 2017
From: ALKERMES PHARMA IRELAND LIMITED
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 041846/0029 →
SECURITY INTEREST Recorded Jun 25, 2014
From: ALKERMES PHARMA IRELAND LIMITED
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 033244/0523 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2014
From: ZEIDAN, TAREK A.; DUNCAN, SCOTT; HENCKEN, CHRISTOPHER P.; WYNN, THOMAS ANDREW; SANRAME, CARLOS N.
To: ALKERMES PHARMA IRELEAND LIMITED
Reel/Frame 032983/0200 →