Prodrugs of fumarates and their use in treating various diseases
View Patent ↗The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
1. A compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:
wherein:
R 1 is unsubstituted C 1 -C 6 alkyl;
L a is unsubstituted C 1 -C 6 alkyl linker; and
R 2 is H, unsubstituted C 1 -C 6 alkyl, unsubstituted C 2 -C 6 alkenyl, or unsubstituted C 2 -C 6 alkynyl.
2. The compound of claim 1 , wherein R 1 is methyl.
3. The compound of claim 1 , wherein L a is an unsubstituted C 1 -C 3 alkyl.
4. The compound of claim 1 , wherein L a is an unsubstituted C 2 alkyl.
5. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 3 alkyl.
6. The compound of claim 1 , wherein R 2 is an unsubstituted C 1 -C 2 alkyl.
7. The compound of claim 1 , wherein R 2 is methyl.
8. The compound of claim 1 , having structure: