IP Library › Granted Patent US 9,415,043
Granted Patent B2
US 9,415,043 · App. 14/213,961 · Granted Aug 16, 2016

Combination therapy

Inventors: Casey Kopczynski (Chapel Hill, NC); Cheng-Wen Lin (Raleigh, NC); Jill Marie Sturdivant (Chapel Hill, NC); Mitchell A. deLong (Chapel Hill, NC)
Assignee: Aerie Pharmaceuticals, Inc.
A61K31/4725A61K31/472A61K31/557A61K31/559A61K31/5575C07D217/22C07D409/12
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Quick Facts
Patent No.
US 9,415,043
App. No.
14/213,961
Granted
Aug 16, 2016
Kind
B2
Abstract

Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.

Claims (4)

1. A compound selected from the group consisting of:

a) (R)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimesylate;

b) (S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimesylate; and

c) (rac)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimesylate.

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2024
From: AERIE PHARMACEUTICALS, INC.
To: ALCON INC.
Reel/Frame 067822/0168 →
RELEASE OF SECURITY INTEREST Recorded Sep 5, 2019
From: DEERFIELD PRIVATE DESIGN FUND III, L.P.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 050276/0807 →
RELEASE OF SECURITY INTEREST Recorded Jul 23, 2018
From: DEERFIELD PARTNERS, L.P.; DEERFIELD PRIVATE DESIGN FUND III, L.P.; DEERFIELD SPECIAL SITUATIONS FUND, L.P.; DEERFIELD MANAGEMENT COMPANY, L.P.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 046431/0600 →
RELEASE OF SECURITY INTEREST Recorded Jul 23, 2018
From: DEERFIELD PARTNERS, L.P.; DEERFIELD PRIVATE DESIGN FUND III, L.P.; DEERFIELD SPECIAL SITUATIONS FUND, L.P.; DEERFIELD MANAGEMENT COMPANY, L.P.
To: AERIE DISTRIBUTION, INC.
Reel/Frame 046431/0500 →
SECURITY INTEREST Recorded Jul 23, 2018
From: AERIE PHARMACEUTICALS, INC.
To: DEERFIELD PRIVATE DESIGN FUND III, L.P.
Reel/Frame 046432/0307 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2017
From: AERIE DISTRIBUTION, INC.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 041754/0402 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2017
From: AERIE PHARMACEUTICALS, INC.
To: AERIE DISTRIBUTION, INC.
Reel/Frame 041754/0369 →
SECURITY INTEREST Recorded Sep 11, 2014
From: AERIE PHARMACEUTICALS, INC.
To: DEERFIELD MANAGEMENT COMPANY, L.P., AS AGENT; DEERFIELD PARTNERS, L.P.; DEERFIELD INTERNATIONAL MASTER FUND, L.P.; DEERFIELD PRIVATE DESIGN FUND III, L.P.; DEERFIELD SPECIAL SITUATIONS FUND, L.P.; DEERFIELD SPECIAL SITUATIONS INTERNATIONAL MASTER FUND, L.P.
Reel/Frame 033726/0043 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2014
From: KOPCZYNSKI, CASEY; LIN, CHENG-WEN; STURTIVANT, JILL MARIE; DELONG, MITCHELL A.
To: AERIE PHARMACEUTICALS, INC.
Reel/Frame 033606/0233 →
Continuity (2)
Provisional Application 61787883 · Mar 15, 2013
Related Publication 20140275161A1 · Sep 18, 2014