Systems, devices, and methods for bodily fluid separation materials
In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.
1. A bodily fluid separation material comprising:
a formed component capture region formed of a first material and having an anti-hemolytic surface coating not comprising the first material;
a second component capture region formed of a first material and without the anti-hemolytic surface coating not comprising the first material;
a bodily fluid pass-through region formed of the first material and comprising pass-through openings sized so that formed components do not enter the bodily fluid pass-through region and a reduced amount of anti-hemolytic material coating the first material of the bodily fluid pass-through region relative to than the capture region, wherein the capture region has openings sized larger than said pass-through openings and wherein the separation material is substantially planar.
2. The separation material of claim 1 wherein at least a portion of the separation material comprises a polyethersulfone.
3. The separation material of claim 1 wherein at least a portion of the separation material comprises an asymmetric polyethersulfone.
4. The separation material of claim 1 wherein at least a portion of the separation material comprises polyarylethersulfone.
5. The separation material of claim 1 wherein at least a portion of the separation material comprises an asymmetric polyarylethersulfone.
6. The separation material of claim 1 wherein at least a portion of the separation material comprises a polysulfone.
7. The separation material of claim 1 wherein the separation material comprises an asymmetric polysulfone.
8. The separation material of claim 1 wherein the anti-hemolytic surface layer comprises single and/or double alkyl chain N-oxides of tertiary amines (NTA).
9. The separation material of claim 1 wherein the formed component capture region defines a first filter region of the separation material having an anti-hemolytic coating and pore spacing sized to constrain formed blood components therein;
wherein the bodily fluid pass-through region defines a second filter region of the separation material having pore spacing smaller than pore spacing of the first filter region with pores sized so that formed components do not enter the second filter region and configured to have an amount of anti-hemolytic coating less than that of the first region.
10. The separation material of claim 9 the separation material comprises at least two separate separation materials.
11. The separation material of claim 9 further comprising at least another region of the separation material between the first region and the second region.
12. The separation material of claim 9 where the first region is in fluid communication with the second region.
13. The separation material of claim 9 where the first region is spaced apart from the second region.
14. The separation material of claim 1 wherein the formed component capture and a bodily fluid pass-through region comprise a percolating network.
15. A method of forming a bodily fluid separation material comprising:
coating the separation material with an anti-hemolytic coating on a first region, a second region and a third region of the separation material;
reducing anti-hemolytic effect of the second region and third region of the separation material relative to the first region by removing a portion of the anti-hemolytic coating from the second region, wherein the separation material is configured such that bodily fluid passes through the first region prior to reaching the second region; wherein the separation material is substantially planar and wherein the first region further comprises an anti-coagulant material in addition to the anti-hemolytic coating.
16. A method of forming a bodily fluid separation material comprising:
coating at least a first region of the separation material with an anti-hemolytic coating;
not coating at least second region of the separation material with the anti-hemolytic coating;
wherein the separation material is substantially planar and wherein the first region further comprises an anti-coagulant material in addition to the anti-hemolytic coating.