IP Library Granted Patent US 8,964,286
Granted Patent B2
US 8,964,286 · App. 14/221,418 · Granted Feb 24, 2015

System and device for non-destructive Raman analysis

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Quick Facts
Patent No.
US 8,964,286
App. No.
14/221,418
Granted
Feb 24, 2015
Kind
B2
Abstract

A Raman microspectrometer system extends the optical reach and analysis range of an existing Raman microspectrometer to allow analysis and/or repair of an oversized sample. The Raman microspectrometer system includes an extender for extending the optical reach of the existing microspectrometer and a supplemental stage which extends the analysis range of the existing microspectrometer by providing travel capabilities for non-destructive analysis of an entire oversized sample. Such an arrangement decreases manufacturing costs associated with testing oversized samples such as mammography panels, enabling analysis and/or repair to be performed without destruction.

Claims (22)

1. A Raman microspectrometer system for non-destructive analysis of an oversized sample that includes amorphous selenium comprising:

a Raman microspectrometer comprising an optical microscope coupled to a spectrometer by an optical transfer tube, the optical microscope comprising a lens and a stage; and

an optical extender removably coupled to the optical microscope and having a proximal orifice aligned with the lens and a distal orifice, the optical extender for extending an optical reach of the microscope to the distal orifice, wherein a sensitivity of the Raman microspectrometer to some molecular vibrations corresponding to crystallized selenium is increased with the optical reach of the microscope extended and decreased with the optical reach of the microscope not extended.

2. The Raman microspectrometer of claim 1 , wherein the extender comprises a plurality of mirrors including a first minor positioned adjacent to the proximal orifice and a second mirror positioned adjacent to the distal orifice, and wherein the first mirror is positioned to direct an optical signal between the proximal orifice and the second minor and the second minor is positioned to direct the optical signal between the first mirror and the distal orifice.

3. The Raman microspectrometer of claim 1 wherein a strength of the lens is adjustable.

4. The Raman microspectrometer of claim 1 further comprising a supplemental stage, coupled to a controller of the stage of the optical microscope, for moving the oversized sample along a travel distance along the at least one track in at least one of a x, y and z dimensions that exceeds a travel capability of the stage of the optical microscope in a corresponding dimension, wherein the supplemental stage comprises a motorized stage wherein travel distances of the supplemental stage correspond to a size of a mammography imaging panel.

5. The Raman microspectrometer of claim 4 wherein the supplemental stage moves along at least the z-axis and wherein the Raman microspectrometer system is configured to analyze the oversized sample at different depths.

6. The Raman microspectrometer of claim 1 wherein the extender is rotatable around the proximal orifice.

7. The Raman microspectrometer of claim 1 wherein movement of the extender is software controlled.

8. The Raman microspectrometer of claim 1 wherein the extender is a telescoping extender.

9. The Raman microspectrometer of claim 1 wherein the extender is configured to variably extend.

10. The Raman microspectrometer of claim 9 wherein movement of the extender is software controlled.

11. The Raman microspectrometer of claim 1 further comprising a lens mounting plate surrounding the distal orifice.

12. The Raman microspectrometer of claim 11 wherein the extender comprises a mounting plate positioned proximate to the proximal orifice, wherein the mounting plate conforms in shape to the lens mounting plate and wherein the mounting plate secures the extender to a lens mount of the optical microscope.

13. The Raman microspectrometer of claim 12 wherein the mounting plate is a first mounting plate, and wherein the extender further comprises a second mounting plate positioned around the distal orifice and configured to accept the lens.

14. The Raman microspectrometer of claim 1 wherein a housing of the extender comprises wave guide materials.

15. The apparatus of claim 14 wherein the waveguide materials are selected from a group including liquid optical materials and solid optical materials.

16. The Raman microspectrometer of claim 1 wherein the extender comprises a suspension arm for supporting of the extender on a body of the optical microscope.

17. The Raman microspectrometer of claim 16 wherein the suspension arm mounts to and corresponds in shape with a body of the microscope so that the suspension arm hangs from the lens.

18. The Raman microspectrometer of claim 1 wherein the system is configured to be less sensitive to layers above or below a focal plane of the system.

19. The Raman microspectrometer of claim 1 further comprising a motor disposed above the rails and operably coupled to the supplemental stage to control the movement of the supplemental stage in the x and y dimensions.

20. The Raman microspectrometer of claim 1 , wherein the track is an elevated elongated structure above a base of the supplemental stage.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 032753/0942 Recorded Jun 3, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035813/0001 →
SECURITY INTEREST Recorded Apr 25, 2014
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK, USA
Reel/Frame 032753/0942 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2014
From: MAZZIO, VICTOR
To: HOLOGIC, INC.
Reel/Frame 032496/0114 →