Artificial skeletal material and constructs formed therefrom
View Patent ↗A bioresorbable skeletal construct member formed from an osteoinductive composition comprising autogenic bone and an extracellular matrix (ECM) material, the construct member being configured to induce osteoanagenesis and angiogenesis when implanted proximate endogenous bone and tissue.
1. A prosthetic skeletal construct, comprising:
a bioresorbable construct comprising an osteoinductive composition, said osteoinductive composition comprising autogenic bone marrow and acellular extracellular matrix (ECM) from a mammalian tissue source, said construct member being configured to induce osteoanagenesis and angiogenesis when said construct member is implanted proximate endogenous bone and tissue.
2. The skeletal construct of claim 1 , wherein said osteoinductive composition further comprises polyurethane urea.
3. The skeletal construct of claim 1 , wherein said osteoinductive composition comprises at least 20% of said ECM.
4. The skeletal construct of claim 1 , wherein said osteoinductive composition comprises at least 50% of said ECM.
5. The skeletal construct of claim 1 , wherein said comprises small intestine submucosa (SIS).
6. The skeletal construct of claim 1 , wherein said mammalian tissue source comprises an adolescent mammalian tissue source.
7. The skeletal construct of claim 1 , wherein said osteoinductive composition further comprises at least one exogenously added biologically active agent.
8. The skeletal construct of claim 7 , wherein said biologically active agent comprises an osteogenic agent selected from the group consisting of TGF-β1, TGF-β2, TGF-β3, TGF-β4, and TGF-β5.