Acetylcysteine compositions and methods of use thereof
A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.
1. A method of treating acetaminophen overdose in a patient, comprising:
intravenously administering an acetylcysteine composition to the patient at a dosage of 300 mg/kg acetylcysteine over 20 or 21 hours;
measuring the level of AST or ALT in the patient following the administration of 300 mg/kg acetylcysteine,
determining whether acetylcysteine therapy should be continued based on the outcome of the AST or ALT level measurement,
continuing the administration of the acetylcysteine composition to the patient via a 3-bag infusion regimen;
wherein the continued administration comprises a first dosage of 150 mg/kg of acetylcysteine over 60 minutes, followed by a second dosage of 50 mg/kg of acetylcysteine over 4 hours, followed by a third dosage of 100 mg/kg of acetylcysteine over 16 hours.
2. The method of claim 1 , wherein the acetylcysteine composition contains less than 0.05% EDTA.
3. The method of claim 1 , wherein the acetylcysteine composition contains less than 0.05% chelating agents.
4. The method of claim 1 , wherein the acetylcysteine composition is prepared in an aqueous solution of 5% dextrose, 0.45% sodium chloride, 0.90% sodium chloride, or water for injection prior to administration.
5. The method of claim 1 , wherein the 300 mg/kg of acetylcysteine is administered via a 2-bag infusion regimen comprising administering a first dosage of 200 mg/kg of acetylcysteine over 4 hours, followed by a second dosage of 100 mg/kg of acetylcysteine over 16 hours.
6. The method of claim 1 , wherein the 300 mg/kg of acetylcysteine is administered via a 3-bag infusion regimen comprising administering a first dosage of 150 mg/kg of acetylcysteine over 60 minutes, followed by a second dosage of 50 mg/kg of acetylcysteine over 4 hours, followed by a third dosage of 100 mg/kg of acetylcysteine over 16 hours.
7. A method of treating acetaminophen overdose, comprising:
intravenously administering an acetylcysteine composition to a patient in need thereof at a dosage of 300 mg/kg acetylcysteine over 20 or 21 hours; and
continuing the administration of the acetylcysteine composition to the patient via a 3-bag infusion regimen, wherein the continued administration comprises a first dosage of 150 mg/kg of acetylcysteine over 60 minutes, followed by a second dosage of 50 mg/kg of acetylcysteine over 4 hours, followed by a third dosage of 100 mg/kg of acetylcysteine over 16 hours.
8. The method of claim 7 , wherein the acetylcysteine composition contains less than 0.05% EDTA.
9. The method of claim 7 , wherein the acetylcysteine composition contains less than 0.05% chelating agents.
10. The method of claim 7 , wherein the 300 mg/kg of acetylcysteine is administered via a 2-bag infusion regimen comprising administering a first dosage of 200 mg/kg of acetylcysteine over 4 hours, followed by a second dosage of 100 mg/kg of acetylcysteine over 16 hours.
11. The method of claim 7 , wherein the 300 mg/kg of acetylcysteine is administered via a 3-bag infusion regimen comprising administering a first dosage of 150 mg/kg of acetylcysteine over 60 minutes, followed by a second dosage of 50 mg/kg of acetylcysteine over 4 hours, followed by a third dosage of 100 mg/kg of acetylcysteine over 16 hours.