Mesenchymal Stem Cells Expressing TNF-alpha Receptors
Mesenchymal stem cells which express TNF-α receptor Type I in an amount of at least 13 pg/10 6 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.
1 . A composition comprising isolated mesenchymal stem cells wherein substantially all of said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 13 pg/10 6 cells; and wherein said mesenchymal stem cells are non-transfected cells.
2 . The composition of claim 1 wherein said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 15 pg/10 6 cells.
3 . The composition of claim 2 wherein said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 18 pg/10 6 cells.
4 . The composition of claim 1 wherein said mesenchymal stem cells are human mesenchymal stem cells.
5 . The composition of claim 1 , further comprising an acceptable pharmaceutical carrier.
6 . The composition of claim 1 , wherein at least 85% of said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 13 pg/10 6 cells.
7 . The composition of claim 1 , wherein 98% of said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 13 pg/10 6 cells.
8 . The composition of claim 1 , wherein all of said mesenchymal stem cells express TNF-α receptor Type I in an amount of at least 13 pg/10 6 cells.