Method for measuring concentration of analyte in blood sample, and biosensor system

1. A method for measuring a concentration of an analyte in a blood sample using a sensor chip, the sensor chip including a capillary and a pair of electrodes, the method including:

acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result;

acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and

measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b, wherein

the first voltage is between 1.0V and 3.0V, and the second voltage is between 0.05V and 1.0V.

2. The method according to claim 1 , further includes correcting the data b based on the data a.

3. The method according to claim 1 , further includes:

calculating a concentration x of the analyte in the blood sample based on the data b; and

correcting the concentration x based on the data a.

4. The method according to claim 1 , further includes:

calculating a temperature t of the blood sample based on the data a; and

correcting the data b based on the temperature t.

5. The method according to claim 1 , further includes:

calculating a temperature t of the blood sample based on the data a;

calculating a concentration x of the analyte in the blood sample based on the data b; and

correcting the concentration x based on the temperature t.

6. The method according to claim 1 , wherein

the data a is acquired before the data b is acquired.

7. A method for measuring a concentration of an analyte in a blood sample using a sensor chip, the sensor chip including a capillary and a pair of electrodes, the method including:

acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result;

acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and

measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b, wherein

the data a related to the temperature of the blood sample contains a temperature, and

the data b related to the concentration of the analyte contains a glucose concentration.

8. The method according to claim 7 , wherein

the data b related to the concentration of the analyte contains hematocrit,

the data a related to the temperature of the blood sample contains a temperature, and

the data b related to the concentration of the analyte further contains a glucose concentration.

9. The method according to claim 7 , wherein

the data b related to the concentration of the analyte contains a concentration or an amount of a reducing substance,

the data a related to the temperature of the blood sample contains a temperature, and

the data b related to the concentration of the analyte further contains a glucose concentration.

10. The method according to claim 7 , wherein

at least two features of the data contained in the data a and the data b are measured at the same time,

the data a related to the temperature of the blood sample contains a temperature, and

the data b related to the concentration of the analyte contains a glucose concentration.

11. The method according to claim 10 , wherein

the data contained in the data a and the data contained in the data b are measured independently.

12. The method according to claim 7 , wherein

the data contained in the data a and the data contained the data b are measured in order of temperature, glucose concentration, concentration or amount of a reducing substance, and hematocrit,

the data a related to the temperature of the blood sample contains a temperature, and

the data b related to the concentration of the analyte contains a glucose concentration.

13. The method according to claim 10 , wherein

the data contained in the data a and the data contained in the data b are measured through independent electrodes.