Curing accelerator and method of making
A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
1. A sterilized cyanoacrylate adhesive composition comprising
99% or more by weight, based on the weight of the adhesive composition, of 2-octyl cyanoacrylate, mixed together with
100 to 1000 parts per million, based on the weight of the adhesive composition, of a 18-crown-6 ether,
a free radical stabilizer, and
an anionic vapor phase stabilizer;
wherein the composition is sterilized by irradiation, and the viscosity of the sterilized composition is 5 to 70 cp following storage for twelve days at 80° C.
2. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the sterilized composition has a viscosity of 5 to 30 cp following storage for twelve days at 80° C.
3. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the composition has been treated with a particulate agent selected from the group consisting of vinyl pyrrolidone polymers and co-polymers.
4. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the anionic vapor phase stabilizer is present in the composition at a concentration of less than 20 parts per million.
5. The sterilized cyanoacrylate adhesive composition of claim 3 , wherein the free radical stabilizer is butylated hydroxyl anisole and the anionic vapor phase stabilizer is sulfur dioxide.
6. The sterilized cyanoacrylate adhesive composition of claim 1 , further comprising therapeutic-loaded nanoparticles.
7. The sterilized cyanoacrylate adhesive composition of claim 1 , wherein the irradiation is gamma irradiation, electron beam irradiation, microwave irradiation, or ultraviolet radiation.
8. A kit, comprising the sterilized cyanoacrylate adhesive composition of claim 1 and an applicator.
9. The kit of claim 8 , wherein said sterilized cyanoacrylate adhesive composition has been treated with a particulate agent selected from the group consisting of vinyl pyrrolidone polymers and co-polymers.
10. The kit of claim 8 , wherein the anionic vapor phase stabilizer is present in the composition at a concentration of less than 20 parts per million.
11. The kit of claim 9 , wherein the free radical stabilizer is butylated hydroxyl anisole and the anionic vapor phase stabilizer is sulfur dioxide.
12. The kit of claim 8 , wherein the sterilized cyanoacrylate adhesive composition further comprises therapeutic-loaded nanoparticles.
13. A method of making the sterilized cyanoacrylate adhesive composition of claim 1 , comprising
mixing 99% or more by weight, based on the weight of the adhesive composition, of 2-octyl cyanoacrylate with a free radical stabilizer, an anionic vapor phase stabilizer, and 100 to 1000 parts per million, based on the weight of the adhesive composition, of a 18-crown-6 crown ether to form a cyanoacrylate adhesive composition, and
sterilizing the composition by irradiating the composition,
wherein the sterilized composition has a viscosity of 5 to 70 cp following storage for twelve days at 80° C.
14. The method of claim 13 , wherein the sterilized composition has a viscosity of 5 to 30 cp following storage for twelve days at 80° C.
15. The method of claim 13 , further comprising treating the composition with a particulate agent selected from the group consisting of vinyl pyrrolidone polymers and co-polymers.
16. The method of claim 13 , wherein the anionic vapor phase stabilizer is present in the composition at a concentration of less than 20 parts per million.
17. The method of claim 15 , wherein the free radical stabilizer is butylated hydroxyl anisole and the anionic vapor phase stabilizer is sulfur dioxide.
18. The method of claim 13 , further comprising mixing therapeutic-loaded nanoparticles together with the cyanoacrylate adhesive composition.
19. The method of claim 13 , wherein the sterilizing comprises irradiating the composition with gamma irradiation, electron beam irradiation, microwave irradiation, or ultraviolet radiation.
20. The method of claim 13 , wherein the sterilizing comprises gamma irradiation.
21. A method of sealing tissue, comprising
applying the sterilized cyanoacrylate adhesive composition of claim 1 to a patient's tissue, and
allowing the sterilized composition to cure.