Water soluble antimicrobial composition
View Patent ↗The present invention provides for antimicrobial compositions, methods of preparing the antimicrobial compositions, methods of using the antimicrobial compositions, and/or kits that include the antimicrobial compositions. The antimicrobial compositions can be in a dry, solid (e.g., powdered) form, or can be in a liquid (e.g., aqueous) form.
1. A method of eliminating or lowering malodor associated with a microorganism, the method comprising contacting the microorganism with a liquid, aqueous antimicrobial composition comprising:
(a) about 0.01 to about 4.0 wt. % of 3-(trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride,
(b) about 0.1 to about 4.0 wt. % of polyvinyl alcohol (PVA),
(c) about 18 to about 99.9 wt. % water,
(d) 0 to about 80.0 wt. % of ethanol,
(e) 0 to about 2.0 wt. % fragrance, and
(f) 0 to about 0.004 wt. % of an anti-foaming agent
which comprises less than 0.1 wt. % of undissolved solid particulates,
for a sufficient period of time effective to eliminate or lower the malodor;
wherein at least 95 mol. % of the 3-(trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride is complexed with the polyvinyl alcohol (PVA).
2. A method of eliminating or lowering malodor associated with a microorganism, the method comprising contacting the microorganism with a liquid, aqueous antimicrobial composition comprising:
(a) about 0.5 wt. % of 3-(trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride,
(b) about 1.0 wt. % of polyvinyl alcohol (PVA),
(c) about 88.3 wt. % of water,
(d) about 10.0 wt. % of ethanol,
(e) about 0.2 wt. % fragrance, and
(f) about 0.002 wt. % of an anti-foaming agent
which comprises less than 0.1 wt. % of undissolved solid particulates,
for a sufficient period of time effective to eliminate or lower the malodor;
wherein at least 95 mol. % of the 3-(trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride is complexed with the polyvinyl alcohol (PVA).
3. The method of claim 1 or 2 , wherein the microbe or microorganism is selected from the group consisting of a virus, fungus, mold, slime mold, algae, yeast, mushroom and bacterium.
4. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is applied to a substrate by at least one of spraying, dipping, brushing, and rolling the substrate with the antimicrobial composition.
5. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is formulated such that at least 90 mol. % of the antimicrobial located on the substrate will remain stable on the substrate, at 20° C. and at 50% relative humidity, when exposed to the atmosphere, for at least 3 months.
6. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is applied to a substrate with a liquid applicator comprising at least one of a spray bottle, wipe, cloth, sponge, non-woven fabric, and woven fabric.
7. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is formulated such that at least 90 mol. % of aqueous antimicrobial composition will remain stable at 20° C. and at 50% relative humidity, when exposed to the atmosphere, for at least 9 months.
8. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition comprises less than 0.1 wt. % methanol.
9. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is non-toxic, such that the LD 50 in rats is greater than 2 ml/kg of body mass.
10. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition comprises less than 0.1 wt. % heavy metals.
11. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition comprises less than 0.1 wt. % poly-chlorinated phenols (PCPs).
12. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is a sprayable composition.
13. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is applied to a substrate selected from the group consisting of athletic equipment, athletic gear, athletic apparel, and athletic footwear.
14. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is applied to a topical surface of at least one of a mammal, non-woven fabric, woven fabric, natural textile, synthetic textile, organic particulate, inorganic particulate, fiber, agglomerate, foam, film, cellulosic material, metal, plastic, natural rubber, synthetic rubber, glass, paint, stain, adhesive, stone, grout, fiberglass, medical device, clothing apparel, sporting equipment, wood, concrete, construction product, building product, and activated carbon.
15. The method of claim 1 or 2 , wherein the liquid, aqueous antimicrobial composition is applied to a topical surface of at least one of polyester fabric, synthetic polyester fabric, non-engineered polyester fabric, performance apparel, moisture wicking performance fabric, delicate moisture wicking performance fabric, and moisture wicking performance apparel.
16. The method of claim 1 or 2 , wherein a substrate is treated one or more times with the liquid, aqueous antimicrobial composition.
17. The method of claim 1 or 2 , wherein a substrate is treated one or more times with the liquid, aqueous antimicrobial composition, to provide a coating or film on the substrate, and the resulting film or coating remains stable and retains the antimicrobial properties for at least 1 year.
18. The method of claim 1 or 2 , wherein a substrate is treated one or more times with the liquid, aqueous antimicrobial composition, to provide a coating or film on the substrate, and the resulting film or coating remains stable and retains the antimicrobial properties for 1 to 5 years.