Human gastrointestinal microbiome modulating food supplement for improving blood glucose regulation
A formulation to increase the ratio of gastrointestinal microbiota in phylum Bacteroidetes to microbiota of Firmicutes phylum preferably includes about 20-60 mg/kg of body weight of fermentable fiber, about 10-30 mg/kg of body weight of beta glucan and about 20-60 mg/kg of body weight of blueberry extracts or any fruit or berry ingredient preparation containing similar phenolics. This formulation is preferably used to control body weight, body composition, and blood glucose regulation, preferably in humans, and is preferably administered orally, preferably twice per day.
1. A human gastrointestinal microbiome modulating food supplement for improving blood glucose regulation and having fewer than 200 usable Calories per therapeutic dose, comprising:
a) at least about 3 g of purified inulin
b) at least about 2 g of a dietary β-glucan extract; and
c) blueberry pomace, or an extract thereof, comprising at least about 700 mg of dietary polyphenol compounds.
2. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein the blueberry pomace, or an extract thereof, comprises at least about 4.7 g of dietary polyphenol compounds.
3. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein
the dietary β-glucan is extracted from a member of the group consisting of: baker's yeast, oat, barley, wheat, fungi, mushrooms, bacteria, and combinations thereof.
4. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein
the dietary β-glucan includes β-glucan extracted from oat.
5. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein the inulin is agave inulin.
6. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein the dietary β-glucan includes β-glucan extracted from wheat.
7. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein the dietary β-glucan includes β-glucan extracted from barley.
8. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein the blueberry pomace extract is present.
9. The human gastrointestinal microbiome modulating food supplement of claim 1 , comprising fewer than 150 usable Calories per therapeutic dose.
10. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein:
a) inulin is present in an amount of 4-40% by weight;
b) the dietary β-glucan is present in an amount of 2-21% by weight; and
c) the dietary polyphenol compounds are present in an amount of 0.5-9% by weight.
11. The human gastrointestinal microbiome modulating food supplement of claim 1 , wherein:
a) inulin is present in an amount of 6.5-28% by weight;
b) the dietary β-glucan is present in an amount of 3.5-14% by weight; and
c) the dietary polyphenol compounds are present in an amount of 1-6% by weight.
12. The human gastrointestinal microbiome modulating food supplement of claim 1 , formulated as: a food preparation, medical food, beverage, suspension, powder, bar, smoothie, yogurt, shake, capsule, or tablet.
13. A medical food composition, comprising: the human gastrointestinal microbiome modulating food supplement of claim 1 .
14. A human gastrointestinal microbiome modulating medical food composition, for dietary management in a diabetic patient that is being treated with metformin, comprising:
a) at least about 3 g of purified inulin;
b) at least about 2 g of a β-glucan extracted from oat; and
c) blueberry pomace, or an extract thereof, comprising at least about 700 mg of a dietary polyphenol compound.