Antibacterial compounds and methods for use

1. A compound of Formula (I):

or a form thereof, wherein

R 1 is phenyl, optionally substituted with one, two or three substituents each selected from R 5 and one additional substituent selected from R 6 ;

R 2 is halogen, cyano, C 1-8 alkyl, halo-C 1-8 alkyl, hydroxyl-C 1-8 alkyl, formyl-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynl, carboxyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl, C 3-14 cycloalkyl, C 3-8 cycloalkyl-oxy, aryl or aryl-C 1-8 alkyl, wherein each instance of aryl is optionally substituted with one halogen substituent;

R 3 is hydroxyl;

R 4 is hydrogen;

R 5 is halogen, hydroxyl, oxo, cyano, nitro, C 1-8 alkyl, hydroxyl-C 1-8 alkyl, halo-C 1-8 alkyl, C 1-8 alkoxy, halo-C 1-8 alkoxy, C 1-8 alkyl-thio, carboxyl, C 1-8 alkyl-carbonyl, C 1-8 alkoxy-carbonyl, amino-carbonyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, C 2-8 alkenyl-amino, (C 2-8 alkenyl) 2 -amino, C 2-8 alkynyl-amino, (C 2-8 alkynyl) 2 -amino, amino-C 1-8 alkyl, C 1-10 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl, C 2-8 alkenyl-amino-C 1-8 alkyl, (C 2-8 alkenyl) 2 -amino-C 1-8 alkyl, C 2-8 alkynyl-amino-C 1-8 alkyl, (C 2-8 alkynyl) 2 -amino-C 1-8 alkyl, halo-C 1-8 alkyl-amino, (halo-C 1-8 alkyl) 2 -amino, halo-C 1-8 alkyl-amino-C 1-8 alkyl, (halo-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl-amino, (C 1-8 alkoxy-C 1-8 alkyl,C 1-8 alkyl)-amino, (C 1-8 alkoxy-C 1-8 alkyl) 2 -amino, C 1-8 alkoxy-C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkoxy-C 1-8 alkyl,C 1-8 alkyl)-amino-C 1-8 alkyl, (C 1-8 alkoxy-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, amino-C 1-8 alkyl-amino, (amino-C 1-8 alkyl,C 1-8 alkyl)amino, C 1-8 alkyl-amino-C 1-8 alkyl-amino, (C 1-8 alkyl-amino-C 1-8 alkyl,C 1-8 alkyl)amino, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl-amino, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino, amino-C 1-8 alkyl-amino-C 1-8 alkyl, (amino-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl-amino-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl-amino-C 1-8 alkyl, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino-C 1-8 alkyl, hydroxyl-amino, hydroxyl-C 1-8 alkyl-amino, (hydroxyl-C 1-8 alkyl,C 1-8 alkyl)amino, (hydroxyl-C 1-8 alkyl) 2 -amino, hydroxyl-C 1-8 alkyl-amino-C 1-8 alkyl, (hydroxyl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, hydroxyl-C 1-8 alkyl-amino-C 1-8 alkyl-amino, (hydroxyl-C 1-8 alkyl-amino-C 1-8 alkyl,C 1-8 alkyl)amino, (hydroxyl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl-amino, [(hydroxyl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl,C 1-8 alkyl]amino, (C 1-8 alkyl-carbonyl,C 1-8 alkyl)amino-C 1-8 alkyl, C 1-8 alkyl-amino-carbonyl, (C 1-8 alkyl) 2 -amino-carbonyl or (C 1-8 alkyl) 2 -amino-carbonyl-C 1-8 alkyl-amino-C 1-8 alkyl;

R 6 is C 3-14 cycloalkyl, C 3-14 cycloalkyl-C 1-8 alkyl, C 3-14 cycloalkyl-oxy, C 3-14 cycloalkyl-C 1-8 alkoxy, C 3-14 cycloalkyl-amino, C 3-14 cycloalkyl-amino-C 1-8 alkyl, (C 3-14 cycloalkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (C 3-14 cycloalkyl) 2 -amino-C 1-8 alkyl, C 3-14 cycloalkyl-C 1-8 alkyl-amino-C 1-8 alkyl, (C 3-14 cycloalkyl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (C 3-14 cycloalkyl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, aryl, aryl-C 1-8 alkyl, aryl-C 1-8 alkoxy, aryl-amino, (aryl,C 1-8 alkyl)amino, (aryl) 2 -amino, aryl-amino-C 1-8 alkyl, (aryl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl) 2 -amino-C 1-8 alkyl, aryl-C 1-8 alkyl-amino, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino, (aryl-C 1-8 alkyl) 2 -amino, aryl-C 1-8 alkyl-amino-C 1-8 alkyl, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, heteroaryl, heteroaryl-C 1-8 alkyl, heteroaryl-amino, heteroaryl-C 1-8 alkyl-amino, (heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino, (heteroaryl-C 1-8 alkyl) 2 -amino, heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, (heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, heterocyclyl, heterocyclyl-C 1-8 alkyl, heterocyclyl-oxy, heterocyclyl-C 1-8 alkoxy, heterocyclyl-amino, (heterocyclyl,C 1-8 alkyl)amino, (heterocyclyl) 2 -amino, heterocyclyl-amino-C 1-8 alkyl, (heterocyclyl,C 1-8 alkyl)amino-C 1-8 alkyl, (heterocyclyl) 2 -amino-C 1-8 alkyl, (heterocyclyl,C 3-14 cycloalkyl-C 1-8 alkyl)amino-C 1-8 alkyl, heterocyclyl-C 1-8 alkyl-amino-C 1-8 alkyl, (heterocyclyl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (heterocyclyl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, heterocyclyl-oxy-amino, (heterocyclyl-oxy,C 1-8 alkyl)amino, (heterocyclyl-oxy) 2 -amino, (heterocyclyl-oxy-C 1-8 alkyl,C 1-8 alkyl)amino, heterocyclyl-carbonyl or heterocyclyl-carbonyl-oxy;

wherein each instance of heterocyclyl is optionally substituted with one, two or three substituents each selected from R 7 ; and,

wherein each instance of C 3-14 cycloalkyl, aryl and heteroaryl is optionally substituted with one, two or three substituents each selected from R 8 ;

R 7 is azido, halogen, hydroxyl, oxo, cyano, nitro, C 1-8 alkyl, halo-C 1-8 alkyl, hydroxyl-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl, C 1-8 alkoxy, halo-C 1-8 alkoxy, hydroxyl-C 1-8 alkoxy, carboxyl, C 1-8 alkyl-carbonyl, C 1-8 alkoxy-carbonyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, halo-C 1-8 alkyl-amino, (halo-C 1-8 alkyl) 2 -amino, halo-C 1-8 alkyl-amino-C 1-8 alkyl, (halo-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino-C 1-8 alkyl C 1-8 alkyl-thio, amino-carbonyl, C 1-8 alkyl-amino-carbonyl, (C 1-8 alkyl) 2 -amino-carbonyl, C 1-8 alkyl-carbonyl-amino, (carboxyl-C 1-8 alkyl,C 1-8 alkyl)amino-carbonyl-amino, C 3-14 cycloalkyl, C 3-14 cycloalkyl-amino, aryl, aryl-C 1-8 alkyl, aryl-amino, (aryl,C 1-8 alkyl)amino, (aryl) 2 -amino, aryl-C 1-8 alkyl-amino, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino, (aryl-C 1-8 alkyl) 2 -amino, aryl-C 1-8 alkyl-amino-C 1-8 alkyl, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, aryl-amino-C 1-8 alkyl, (aryl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl) 2 -amino-C 1-8 alkyl, aryl-amino-carbonyl, aryl-C 1-8 alkoxy, aryl-C 1-8 alkoxy-carbonyl-amino, heteroaryl, heteroaryl-C 1-8 alkyl, heteroaryl-amino, (heteroaryl) 2 -amino, heteroaryl-C 1-8 alkyl-amino, (heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino, (heteroaryl-C 1-8 alkyl) 2 -amino, heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, (heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (heteroaryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, heterocyclyl, heterocyclyl-C 1-8 alkyl, heterocyclyl-amino-C 1-8 alkyl or heterocyclyl-oxy;

wherein each instance of C 3-14 cycloalkyl is optionally substituted with one substituent selected from R 9 ;

wherein each instance of aryl is optionally substituted with one substituent selected from R 10 ; and,

wherein each instance of heterocyclyl and heteroaryl is optionally substituted with one substituent selected from R 11 ;

R 8 is azido, halogen, hydroxyl, cyano, nitro, C 1-8 alkyl, halo-C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, halo-C 1-8 alkoxy, carboxyl, C 1-8 alkoxy-carbonyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, C 1-8 alkyl-thio, aryl, aryl-C 1-8 alkoxy, heteroaryl, heterocyclyl, heterocyclyl-C 1-8 alkyl or heterocyclyl-oxy;

R 9 is amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl or aryl-C 1-8 alkyl-amino;

R 10 is halogen; and,

R 11 is halogen, hydroxyl, C 1-8 alkyl, halo-C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkyl, halo-C 1-8 alkoxy, amino, C 1-8 alkyl-amino or (C 1-8 alkyl) 2 -amino; wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

2. The compound of claim 1 , wherein

R 2 is cyano, C 1-8 alkyl, halo-C 1-8 alkyl, hydroxyl-C 1-8 alkyl, formyl-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynl, carboxyl, C 3-14 cycloalkyl, aryl or aryl-C 1-8 alkyl, wherein each instance of aryl is optionally substituted with one halogen substituent;

R 5 is halogen, oxo, cyano, C 1-8 alkyl, hydroxyl-C 1-8 alkyl, C 1-8 alkoxy, carboxyl, amino-carbonyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, (C 2-8 alkenyl) 2 -amino, amino-C 1-8 alkyl, C 1-10 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl, C 2-8 alkenyl-amino-C 1-8 alkyl, C 2-8 alkynyl-amino-C 1-8 alkyl, halo-C 1-8 alkyl-amino, halo-C 1-8 alkyl-amino-C 1-8 alkyl, (hydroxyl-C 1-8 alkyl,C 1-8 alkyl)amino, (C 1-8 alkoxy-C 1-8 alkyl,C 1-8 alkyl)-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl-amino, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino, amino-C 1-8 alkyl-amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl-amino-C 1-8 alkyl, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino-C 1-8 alkyl, (C 1-8 alkyl-carbonyl,C 1-8 alkyl)amino-C 1-8 alkyl or (C 1-8 alkyl) 2 -amino-carbonyl-C 1-8 alkyl-amino-C 1-8 alkyl;

R 6 is C 3-14 cycloalkyl-amino-C 1-8 alkyl, (C 3-14 cycloalkyl,C 1-8 alkyl)amino-C 1-8 alkyl, C 3-14 cycloalkyl-C 1-8 alkyl-amino-C 1-8 alkyl, aryl, aryl-amino, (aryl,C 1-8 alkyl)amino, aryl-amino-C 1-8 alkyl, aryl-C 1-8 alkyl-amino-C 1-8 alkyl, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, heteroaryl, heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, (heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, heterocyclyl, heterocyclyl-C 1-8 alkyl, heterocyclyl-amino-C 1-8 alkyl, (heterocyclyl,C 1-8 alkyl)amino-C 1-8 alkyl, (heterocyclyl,C 3-14 cycloalkyl-C 1-8 alkyl)amino-C 1-8 alkyl, heterocyclyl-C 1-8 alkyl-amino-C 1-8 alkyl or (heterocyclyl-oxy-C 1-8 alkyl,C 1-8 alkyl)amino;

wherein each instance of heterocyclyl is optionally substituted with one, two or three substituents each selected from R 7 ; and,

wherein each instance of heteroaryl is optionally substituted with one, two or three substituents each selected from R 8 ;

R 7 is azido, halogen, hydroxyl, oxo, cyano, C 1-8 alkyl, halo-C 1-8 alkyl, hydroxyl-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkyl, C 1-8 alkoxy, carboxyl, C 1-8 alkyl-carbonyl, C 1-8 alkoxy-carbonyl, amino, C 1-8 alkyl-amino, (C 1-8 alkyl) 2 -amino, amino-C 1-8 alkyl, C 1-8 alkyl-amino-C 1-8 alkyl, (C 1-8 alkyl) 2 -amino-C 1-8 alkyl, [(C 1-8 alkyl) 2 -amino-C 1-8 alkyl,C 1-8 alkyl]amino-C 1-8 alkyl (C 1-8 alkyl) 2 -amino-carbonyl, C 1-8 alkyl-carbonyl-amino, (carboxyl-C 1-8 alkyl,C 1-8 alkyl)amino-carbonyl-amino, C 3-14 cycloalkyl, C 3-14 cycloalkyl-amino, aryl, aryl-C 1-8 alkyl, aryl-amino, (aryl,C 1-8 alkyl)amino, aryl-C 1-8 alkyl-amino, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino, (aryl-C 1-8 alkyl) 2 -amino, aryl-C 1-8 alkyl-amino-C 1-8 alkyl, (aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, (aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, aryl-amino-C 1-8 alkyl, aryl-C 1-8 alkoxy, aryl-C 1-8 alkoxy-carbonyl-amino, heteroaryl, heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, heterocyclyl, heterocyclyl-C 1-8 alkyl, heterocyclyl-amino-C 1-8 alkyl or heterocyclyl-oxy;

wherein each instance of C 3-14 cycloalkyl is optionally substituted with one substituent selected from R 9 ;

wherein each instance of aryl is optionally substituted with one substituent selected from R 10 ; and,

wherein each instance of heterocyclyl and heteroaryl is optionally substituted with one substituent selected from R 11 ;

R 8 is C 1-8 alkyl;

R 9 is amino, (C 1-8 alkyl) 2 -amino or aryl-C 1-8 alkyl-amino;

R 10 is halogen; and,

R 11 is C 1-8 alkyl.

3. The compound of claim 1 , wherein

R 2 is C 1-8 alkyl selected from the group consisting of methyl, ethyl, propyl and isopropyl; hydroxyl-C 1-8 alkyl selected from the group consisting of hydroxyl-methyl, hydroxyl-ethyl and hydroxyl-propyl; formyl-C 1-8 alkyl selected from the group consisting of formylmethyl, formylethyl and formylpropyl; C 3-14 cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl; aryl selected from phenyl; or, aryl-C 1-8 alkyl selected from benzyl.

4. The compound of claim 1 , wherein R 6 is

C 3-14 cycloalkyl-amino-C 1-8 alkyl, wherein C 3-14 cycloalkyl is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;

(C 3-14 cycloalkyl,C 1-8 alkyl)amino-C 1-8 alkyl, wherein C 3-14 cycloalkyl is selected from the group consisting of cyclopropyl, cyclobutyl and cyclopentyl;

C 3-14 cycloalkyl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein C 3-14 cycloalkyl is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl;

aryl, wherein aryl is selected from phenyl;

aryl-C 1-8 alkoxy, wherein aryl is selected from phenyl;

aryl-amino, wherein aryl is selected from phenyl;

(aryl,C 1-8 alkyl)amino, wherein aryl is selected from phenyl;

aryl-amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

aryl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

heteroaryl, wherein heteroaryl is selected from the group consisting of pyrrolyl, thiazolyl, 1H-1,2,3-triazolyl, 1H-tetrazolyl, 2H-tetrazolyl, imidazolyl and pyridinyl;

heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein heteroaryl is selected from the group consisting of pyridin-2-yl, pyridin-3-yl and pyridin-4-yl;

(heteroaryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, wherein heteroaryl is selected from the group consisting of pyridin-3-yl and pyridin-4-yl;

heterocyclyl, wherein heterocyclyl is selected from the group consisting of azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, morpholinyl, 1,4-diazepanyl, 1,3-dioxolanyl, 2,5-dihydro-1H-pyrrolyl, dihydro-1H-imidazolyl, 1,4,5,6-tetrahydropyrimidinyl, 1,2,3,6-tetrahydropyridinyl, tetrahydro-2H-pyranyl, 3,4-dihydroisoquinolin-(1H)-yl, 1,2,3,4-tetrahydroisoquinolinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, (4aR,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-(4aH)-yl, (cis)-octahydrocyclopenta[c]pyrrolyl, hexahydropyrrolo[3,4-b]pyrrol-(1H)-yl, (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-(1H)-yl, (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-(1H)-yl, 5H-pyrrolo[3,4-b]pyridin-(7H)-yl, 5,7-dihydro-6H-pyrrolo[3,4-b]pyridinyl, tetrahydro-1H-pyrrolo[3,4-b]pyridin-(2H,7H,7aH)-yl, hexahydro-1H-pyrrolo[3,4-b]pyridin-(2H)-yl, (4aR,7aR)-hexahydro-1H-pyrrolo[3,4-b]pyridin-(2H)-yl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, (3aR,6aR)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,4R,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,4S,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,5r,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl, 1,3-dihydro-2H-isoindolyl, octahydro-2H-isoindolyl, (3aS)-1,3,3a,4,5,6-hexahydro-2H-isoindolyl, (3aR,4R,7aS)-1H-isoindol-(3H,3aH,4H,5H,6H,7H,7aH)-yl, (3aR,7aS)-octahydro-2H-isoindolyl, (3aR,4R,7aS)-octahydro-2H-isoindolyl, (3aR,4S,7aS)-octahydro-2H-isoindolyl, 2,5-diazabicyclo[2.2.1]heptanyl, 2-azabicyclo[2.2.1]hept-5-enyl, 3-azabicyclo[3.1.0]hexanyl, (1R,5S,6s)-3-azabicyclo[3.1.0]hexanyl, (cis,cis)-3-azabicyclo[3.1.0]hexanyl, 3,6-diazabicyclo[3.1.0]hexanyl, (1S,5R,6R)-3-azabicyclo[3.2.0]heptanyl, (1S,5R,6S)-3-azabicyclo[3.2.0]heptanyl, 5-azaspiro[2.4]heptanyl, 2,6-diazaspiro[3.3]heptanyl, 2,5-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 2,7-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2-azaspiro[4.5]decanyl and 2,8-diazaspiro[4.5]decanyl;

heterocyclyl-C 1-8 alkyl, wherein heterocyclyl is selected from the group consisting of azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, morpholinyl, 1,4-diazepanyl, 1,3-dioxolanyl, 2,5-dihydro-1H-pyrrolyl, dihydro-1H-imidazolyl, 1,4,5,6-tetrahydropyrimidinyl, 1,2,3,6-tetrahydropyridinyl, tetrahydro-2H-pyranyl, 3,4-dihydroisoquinolin-(1H)-yl, 1,2,3,4-tetrahydroisoquinolinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, (4aR,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-(4aH)-yl, (cis)-octahydrocyclopenta[c]pyrrolyl, hexahydropyrrolo[3,4-b]pyrrol-(1H)-yl, (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-(1H)-yl, (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-(1H)-yl, 5H-pyrrolo[3,4-b]pyridin-(7H)-yl, 5,7-dihydro-6H-pyrrolo[3,4-b]pyridinyl, tetrahydro-1H-pyrrolo[3,4-b]pyridin-(2H,7H,7aH)-yl, hexahydro-1H-pyrrolo[3,4-b]pyridin-(2H)-yl, (4aR,7aR)-hexahydro-1H-pyrrolo[3,4-b]pyridin-(2H)-yl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, (3aR,6aR)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,4R,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,4S,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,5r,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl, 1,3-dihydro-2H-isoindolyl, octahydro-2H-isoindolyl, (3aS)-1,3,3a,4,5,6-hexahydro-2H-isoindolyl, (3aR,4R,7aS)-1H-isoindol-(3H,3aH,4H,5H,6H,7H,7aH)-yl, (3aR,7aS)-octahydro-2H-isoindolyl, (3aR,4R,7aS)-octahydro-2H-isoindolyl, (3aR,4S,7aS)-octahydro-2H-isoindolyl, 2,5-diazabicyclo[2.2.1]heptanyl, 2-azabicyclo[2.2.1]hept-5-enyl, 3-azabicyclo[3.1.0]hexanyl, (1R,5S,6s)-3-azabicyclo[3.1.0]hexanyl, (cis,cis)-3-azabicyclo[3.1.0]hexanyl, 3,6-diazabicyclo[3.1.0]hexanyl, (1S,5R,6R)-3-azabicyclo[3.2.0]heptanyl, (1S,5R,6S)-3-azabicyclo[3.2.0]heptanyl, 5-azaspiro[2.4]heptanyl, 2,6-diazaspiro[3.3]heptanyl, 2,5-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 2,7-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2-azaspiro[4.5]decanyl and 2,8-diazaspiro[4.5]decanyl;

heterocyclyl-amino-C 1-8 alkyl, wherein heterocyclyl is selected from the group consisting of azetidin-1-yl and piperidin-4-yl;

(heterocyclyl,C 1-8 alkyl)amino-C 1-8 alkyl, wherein heterocyclyl is selected from the group consisting of piperidin-3-yl and piperidin-4-yl;

(heterocyclyl,C 3-14 cycloalkyl-C 1-8 alkyl)amino-C 1-8 alkyl, wherein heterocyclyl is selected from the group consisting of piperidin-3-yl and piperidin-4-yl;

heterocyclyl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein heterocyclyl is selected from the group consisting of pyrrolidin-2-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl and tetrahydro-2H-pyran-4-yl; or

(heterocyclyl-oxy-C 1-8 alkyl,C 1-8 alkyl)amino selected from tetrahydro-2H-pyran-2-yl-oxy-C 1-8 alkyl,C 1-8 alkyl)amino.

5. The compound of claim 1 , wherein R 6 is

heteroaryl, wherein heteroaryl is selected from the group consisting of 1H-tetrazolyl, imidazolyl, pyrrolyl and 2H-tetrazolyl; or,

heterocyclyl, wherein heterocyclyl is selected from the group consisting of azetidinyl, pyrrolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, morpholinyl, 2,5-dihydro-1H-pyrrolyl, 1,2,3,6-tetrahydropyridinyl, hexahydropyrrolo[3,4-b][1,4]oxazin-(2H)-yl, (4aR,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-(4aH)-yl, (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-(1H)-yl, (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-(1H)-yl, 5,7-dihydro-6H-pyrrolo[3,4-b]pyridinyl, octahydro-6H-pyrrolo[3,4-b]pyridinyl, (3aR,6aR)-hexahydrocyclopenta[c]pyrrol-3a(1H)-yl, (3aR,4R,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,4S,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, (3aR,5r,6aS)-hexahydrocyclopenta[c]pyrrol-(1H)-yl, 1,3-dihydro-2H-isoindolyl, octahydro-2H-isoindolyl, (3aS)-1,3,3a,4,5,6-hexahydro-2H-isoindolyl, (3aR,7aS)-octahydro-2H-isoindolyl, (3aR,4R,7aS)-octahydro-2H-isoindolyl, (3aR,4S,7aS)-octahydro-2H-isoindolyl, 2,5-diazabicyclo[2.2.1]heptanyl, 2-azabicyclo[2.2.1]hept-5-enyl, 3-azabicyclo[3.1.0]hexanyl, 3,6-diazabicyclo[3.1.0]hexanyl, (1R,5S,6s)-3-azabicyclo[3.1.0]hexanyl, (1S,5R,6R)-3-azabicyclo[3.2.0]heptanyl, (1S,5R,6S)-3-azabicyclo[3.2.0]heptanyl, 5-azaspiro[2.4]heptanyl, 2,6-diazaspiro[3.3]heptanyl, 2,5-diazaspiro[3.4]octanyl, 2,6-diazaspiro[3.4]octanyl, 2,7-diazaspiro[3.5]nonanyl, 2,7-diazaspiro[4.4]nonanyl, 2-azaspiro[4.5]decanyl and 2,8-diazaspiro[4.5]decanyl.

6. The compound of claim 1 , wherein R 6 is

heteroaryl, wherein heteroaryl is selected from the group consisting of 1H-tetrazol-5-yl, imidazol-1-yl, pyrrol-1-yl and 2H-tetrazol-2-yl; or,

heterocyclyl, wherein heterocyclyl is selected from the group consisting of azetidin-1-yl, pyrrolidin-1-yl, tetrahydrofuran-2-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, 2,5-dihydro-1H-pyrrol-1-yl, 1,2,3,6-tetrahydropyridin-4-yl, hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl, (4aR,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-4(4aH)-yl, (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl, (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl, 5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl, octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl, (3aR,6aR)-hexahydrocyclopenta[c]pyrrol-3a(1H)-yl, (3aR,4R,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl, (3aR,4S,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl, (3aR,5r,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl, 1,3-dihydro-2H-isoindol-2-yl, octahydro-2H-isoindol-2-yl, (3aS)-1,3,3a,4,5,6-hexahydro-2H-isoindol-2-yl, (3aR,7aS)-octahydro-2H-isoindol-2-yl, (3aR,4R,7aS)-octahydro-2H-isoindol-2-yl, (3aR,4S,7aS)-octahydro-2H-isoindol-2-yl, 2,5-diazabicyclo[2.2.1]heptan-2-yl, 2-azabicyclo[2.2.1]hept-5-en-2-yl, 3-azabicyclo[3.1.0]hexan-3-yl, 3,6-diazabicyclo[3.1.0]hexan-3-yl, (1R,5S,6s)-3-azabicyclo[3.1.0]hexan-3-yl, (1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl, (1S,5R,6R)-3-azabicyclo[3.2.0]heptan-3-yl, (1S,5R,6S)-3-azabicyclo[3.2.0]heptan-3-yl, 5-azaspiro[2.4]heptan-5-yl, 2,6-diazaspiro[3.3]heptan-2-yl, 2,5-diazaspiro[3.4]octan-2-yl, 2,6-diazaspiro[3.4]octan-6-yl, 2,7-diazaspiro[3.5]nonan-2-yl, 2,7-diazaspiro[4.4]nonan-2-yl, 2-azaspiro[4.5]decan-2-yl and 2,8-diazaspiro[4.5]decan-2-yl.

7. The compound of claim 1 , wherein R 7 is

C 3-14 cycloalkyl, wherein C 3-14 cycloalkyl is selected from the group consisting of cyclopropyl and cyclobutyl;

C 3-14 cycloalkyl-amino, wherein C 3-14 cycloalkyl is selected from cyclopropyl;

aryl, wherein aryl is selected from phenyl;

aryl-C 1-8 alkyl, wherein aryl is selected from phenyl;

aryl-amino, wherein aryl is selected from phenyl;

(aryl,C 1-8 alkyl)amino, wherein aryl is selected from phenyl;

aryl-C 1-8 alkyl-amino, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl,C 1-8 alkyl)amino, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl) 2 -amino, wherein aryl is selected from phenyl;

aryl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl,C 1-8 alkyl)amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

(aryl-C 1-8 alkyl) 2 -amino-C 1-8 alkyl, wherein aryl is selected from phenyl;

aryl-C 1-8 alkoxy, wherein aryl is selected from phenyl;

aryl-C 1-8 alkoxy-carbonyl-amino, wherein aryl is selected from phenyl;

heteroaryl, wherein heteroaryl is selected from the group consisting of pyridin-2-yl, pyridin-4-yl, thiazol-2-yl and 1H-1,2,3-triazol-1-yl;

heteroaryl-C 1-8 alkyl-amino-C 1-8 alkyl, wherein heteroaryl is selected from the group consisting of pyridin-2-yl, pyridin-3-yl and pyridin-4-yl;

heterocyclyl, wherein heterocyclyl is selected from the group consisting of pyrrolidin-1-yl and morpholin-4-yl;

heterocyclyl-C 1-8 alkyl, wherein heterocyclyl is selected from pyrrolidin-1-yl; or, heterocyclyl-oxy, wherein heterocyclyl is selected from tetrahydro-2H-pyran-2-yloxy.

8. The compound of claim 1 , wherein the compound of Formula (I) is a compound of Formula (Ia):

or a form thereof; wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

9. The compound of claim 1 , wherein the compound or a form thereof is selected from the group consisting of:

5-benzyl-6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)phenyl]-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-cyclohexyl-6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-5-propyl-1,2-dihydropyridine-3-carboxylic acid

5-cyclopropyl-6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-[2-(piperidin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-methoxy-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(2,4-dimethoxyphenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[2-methyl-4-(pyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-(2,4,6-trimethoxyphenyl)-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-(2,3,4-trimethoxyphenyl)-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-[2-fluoro-4-(piperidin-1-yl)phenyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[2-methoxy-4-(pyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-[2-(pyrrolidin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-methoxy-2-(pyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[2-methoxy-4-(piperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[2-methyl-4-(piperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-2-fluorophenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-2-methylphenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[2-(dimethylamino)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[2-(dimethylamino)-4-methoxyphenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-2-methoxyphenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-3-methylphenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-3-methoxyphenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[3-methoxy-4-(pyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[3-methoxy-4-(piperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[3-methyl-4-(pyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[3-methyl-4-(piperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-(4-fluorophenyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-chlorophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-bromophenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-iodophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-{4-[(3-iodopropyl)amino]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(azetidin-1-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-{4-[(3 S)-3-fluoropyrrolidin-1-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)-3-fluorophenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-5-(propan-2-yl)-1,2-dihydropyridine-3-carboxylic acid

6-[4-(diethylamino)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-[4-(pyrrolidin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

6-{4-[4-(tert-butoxycarbonyl)piperazin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-(1H-imidazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-[4-(piperidin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-{4-[(3R)-3-hydroxypyrrolidin-1-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-{4-[(3R)-3-hydroxypiperidin-1-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-(3-hydroxypyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-{3-[1-(dimethylamino)cyclopropyl]pyrrolidin-1-yl}phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[(3aR,5r,6aS)-5-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-{(3S,4R)-3-[(dibenzylamino)methyl]-4-methylpyrrolidin-1-yl}phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[(3aR,5r,6aS)-5-(benzylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[(3aR,5r,6aS)-5-(dibenzylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[1-(tert-butoxycarbonyl)octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(3-{[benzyl(methyl)amino]methyl}pyrrolidin-1-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-(4-hydroxypiperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[4-(benzyloxy)piperidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-(4-methoxypiperidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[4-(dibenzylamino)piperidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(4-aminopiperidin-1-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-{4-[3-(pyridin-2-yl)pyrrolidin-1-yl]phenyl}-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-{4-[3-(1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl]phenyl}-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-[4-(3-ethyl-3-hydroxypyrrolidin-1-yl)phenyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-[4-(3-hydroxy-3-methylpyrrolidin-1-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[3-(aminomethyl)-3-methylpyrrolidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[3-(dimethylamino)pyrrolidin-1-yl]-2-fluorophenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-{2-fluoro-4-[(3R)-3-hydroxypyrrolidin-1-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-{2-fluoro-4-[(3R)-3-fluoropyrrolidin-1-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[5-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[di(prop-2-en-1-yl)amino]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-[4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-{4-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-2-methylphenyl)-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(2,7-diazaspiro[3.5]nonan-2-yl)phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(2,7-diazaspiro[4.4]nonan-2-yl)phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-(7-methyl-2,7-diazaspiro[4.4]nonan-2-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(2,5-diazaspiro[3.4]octan-2-yl)phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(2,6-diazaspiro[3.3]heptan-2-yl)phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-(4-(ethylamino)phenyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-(methylamino)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-5-(2-oxoethyl)-1,2-dihydropyridine-3-carboxylic acid

6-(4-(dimethylamino)phenyl)-4-hydroxy-5-(2-hydroxyethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-(2,3-dihydroxypropyl)-6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

(E)-6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-5-(prop-1-enyl)-1,2-dihydropyridine-3-carboxylic acid

6-(4-(dimethylamino)phenyl)-4-hydroxy-5-(hydroxymethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(dimethylamino)phenyl)-4-hydroxy-5-(methoxymethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-5-(prop-1-ynyl)-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-(1-methylpiperidin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-(4-(1-ethylpiperidin-4-yl)phenyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-2-oxo-6-(4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-6-(4-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

5-ethyl-4-hydroxy-6-(4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, and

6-(4-(2-(dimethylamino)ethyl)phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

wherein the form of the compound is selected from a free acid, free base, salt, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

10. The compound of claim 1 , wherein the compound or a form thereof is selected from the group consisting of:

5-ethyl-4-hydroxy-2-oxo-6-[4-(piperazin-1-yl)phenyl]-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

5-ethyl-6-{4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-[4-(7-amino-5-azaspiro[2.4]hept-5-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

5-ethyl-4-hydroxy-6-(4-{3-[(methylamino)methyl]pyrrolidin-1-yl}phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-{4-[(3aR,4R,6aS)-4-(methylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-[4-(1,3′-bipyrrolidin-1′-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(3aR,4S,7aS)-4-aminooctahydro-2H-isoindol-2-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

4-hydroxy-5-methyl-6-{4-[(3aR,4R,7aS)-4-(methylamino)octahydro-2H-isoindol-2-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(3aR,4R,7aS)-4-(dimethylamino)octahydro-2H-isoindol-2-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(3aR,4R,7aS)-4-aminooctahydro-2H-isoindol-2-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

6-{4-[(3aR,4R,6aS)-4-(dimethylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(3aR,4R,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(3aR,4S,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

6-(4-{(3aR,7aS)-3a-[(dimethylamino)methyl]octahydro-2H-isoindol-2-yl}phenyl)-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-{4-[(3aR,4S,6aS)-4-(methylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-{4-[(3aR,4S,7aS)-4-(methylamino)octahydro-2H-isoindol-2-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-{4-[(1R,5S,6s)-6-(methylamino)-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[(1R,5S,6s)-6-(dimethylamino)-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-[4-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-4-hydroxy-6-{4-[(3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

5-ethyl-6-{4-[(3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-[4-(3a-cyanooctahydro-2H-isoindol-2-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

6-[4-(1-amino-3-azabicyclo[3.1.0]hex-3-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-[4-(2,8-diazaspiro[4.5]dec-2-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-{4-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]phenyl}-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

6-[4-(2,5-diazabicyclo[2.2.1]hept-2-yl)phenyl]-5-ethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid trifluoroacetate

5-ethyl-4-hydroxy-6-{4-[(3aR,4R,7aS)-4-(methylamino)octahydro-2H-isoindol-2-yl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride, and

5-ethyl-6-{4-[(3 aS)-1,3,3a,4,5,6-hexahydro-2H-isoindol-2-yl]phenyl}-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride;

wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

11. A method of treating a bacterial infection in a subject in need thereof comprising administering an effective amount of a compound of claim 1 to the subject, wherein the bacterial infection results from a bacteria of the phyla selected from the group consisting of Acidobacteria; Actinobacteria; Aquificae; Bacteroidetes; Caldiserica; Chlamydiae; Chlorobi; Chloroflexi; Chrysiogenetes; Cyanobacteria; Deferribacteres; Deinococcus-Thermus; Dictyoglomi; Elusimicrobia; Fibrobacteres; Firmicutes; Fusobacteria; Gemmatimonadetes; Lentisphaerae; Nitrospira; Planctomycetes; Proteobacteria; Spirochaetes; Synergistetes; Tenericutes; Thermodesulfobacteria; Thermomicrobia; Thermotogae; and Verrucomicrobia.

12. The method of claim 11 , wherein the bacterial infection results from a bacteria of the phyla selected from the group consisting of Proteobacteria, Spirochaetes, Bacteriodetes, Chlamydiae, Firmicutes and Actinobacteria.

13. A method of treating a bacterial infection in a subject in need thereof, comprising administering an effective amount of a compound of claim 1 to the subject, wherein the bacterial infection results from a bacterial species selected from the group consisting of Acinetobacter baumannii, Bacillus anthracis, Bacillus subtilis, Enterobacter spp., Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Francisella tularensis, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Mycobacterium tuberculosis, Neisseria spp., Pseudomonas aeruginosa, Shigella spp., Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and Yersinia pestis.

14. The method of claim 11 , wherein the effective amount of the compound or a form thereof is in a range of from about 0.001 mg/Kg/day to about 500 mg/Kg/day.

15. A pharmaceutical composition comprising an effective amount of a compound of claim 1 or a form thereof in admixture with a pharmaceutically acceptable excipient; wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

16. A combination therapy comprising an effective amount of a compound of claim 1 or a form thereof and an effective amount of an antibiotic or antibacterial agent; wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.

17. The combination therapy of claim 16 , wherein the agent is one or more selected from the group consisting of Ciprofloxacin, Enoxacin, Gatifloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Nalidixic acid, Norfloxacin and Ofloxacin.

18. The combination therapy of claim 16 , wherein the agent is one or more selected from the group consisting of Amikacin, Amoxicillin, Ampicillin, Arsphenamine, Azithromycin, Azlocillin, Aztreonam, Bacitracin, Capreomycin, Carbenicillin, Cefaclor, Cefadroxil, Cefalexin, Cefalotin, Cefamandole, Cefazolin, Cefdinir, Cefditoren, Cefixime, Cefoperazone, Cefotaxime, Cefoxitin, Cefpodoxime, Cefprozil, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Cefuroxime, Chloramphenicol, Cilastatin, Clarithromycin, Clavulanate, Clindamycin, Clofazimine, Cloxacillin, Colistin, Cycloserine, Dalfopristin, Dapsone, Daptomycin, Dicloxacillin, Dirithromycin, Doripenem, Doxycycline, Erythromycin, Ethambutol, Ethionamide, Flucloxacillin, Fosfomycin, Furazolidone, Fusidic acid, Gentamicin, Imipenem, Isoniazid, Kanamycin, Lincomycin, Linezolid, Loracarbef, Mafenide, Meropenem, Methicillin, Metronidazole, Mezlocillin, Minocycline, Mupirocin, Nafcillin, Neomycin, Netilmicin, Nitrofurantoin, Oxacillin, Oxytetracycline, Paromomycin, Penicillin G, Penicillin V, Piperacillin, Platensimycin, Polymyxin B, Pyrazinamide, Quinupristin, Rapamycin, Rifabutin, Rifampicin, Rifampin, Rifapentine, Rifaximin, Roxithromycin, Silver sulfadiazine, Spectinomycin, Streptomycin, Sulbactam, Sulfacetamide, Sulfadiazine, Sulfamethizole, Sulfamethoxazole, Sulfanilimide, Sulfasalazine, Sulfisoxazole, Tazobactam, Teicoplanin, Telavancin, Telithromycin, Temocillin, Tetracycline, Thiamphenicol, Ticarcillin, Tigecycline, Tinidazole, Tobramycin, Trimethoprim, Troleandomycin and Vancomycin.

19. The method of claim 13 , wherein the effective amount of the compound or a form thereof is in a range of from about 0.001 mg/Kg/day to about 500 mg/Kg/day; wherein the form of the compound is selected from a free acid, free base, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer, polymorph or tautomer form thereof.