Anti-biofilm compositions and methods for using
The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.
1. A medical device having a coating comprising a polyphenolic composition comprising at least one glycosylated derivative of ellagic acid chosen from ellagic acid xylofuranoside, ellagic acid mannopyranoside, ellagic acid rhamnoside, or combination thereof.
2. The medical device of claim 1 , wherein the polyphenolic composition further comprises ellagic acid.
3. The medical device of claim 2 , wherein the polyphenolic composition further comprises at least one sapogenin.
4. The medical device of claim 1 , wherein the medical device is an implantable medical device.
5. The medical device of claim 4 , wherein the implantable medical device is chosen from a catheter, a cardiac device, an orthopedic device, a breathing tube, or a feeding tube.
6. The medical device of claim 1 , wherein the coating further comprises an antimicrobial agent chosen from an antibiotic, an antifungal agent, or an antiseptic.
7. The medical device of claim 6 , wherein the antimicrobial agent is an antibiotic chosen from amphotericin B, clindamycin, daptomycin, dicloxicillin, minocycline, nafcillin, oxacillin, ramoplanin, rifampin, triclosan, or vancomycin.
8. The medical device of claim 1 , wherein the coating comprises a hydrogel.