IP Library Granted Patent US 9,078,872
Granted Patent B2
US 9,078,872 · App. 14/248,883 · Granted Jul 14, 2015

Antioxidant composition

Inventors: Harry Erfurt (Ulsar, DE); René Schuld (Wedel, DE); Melanie Stürtz (Höxter, DE); Christian Wintermeyer (Höxter, DE); Hans-Jürgen Niemeyer (Holzminden, DE)
Assignee: Symrise AG
A61K31/353A23L1/3002A23L3/3508A23L3/3517A61K8/36A61K8/498A61K31/192A61K31/352A61Q19/00
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Quick Facts
Patent No.
US 9,078,872
App. No.
14/248,883
Granted
Jul 14, 2015
Kind
B2
Abstract

Suggested is an antioxidant composition, comprising (a) caffeic acid, (b) sinapinic acid and, optionally, (c) polyphenols, with the proviso that components (a) and (b) are present in a weight ratio of about 85:15 to about 98:2.

Claims (39)

1. An antioxidant composition, comprising

(a) caffeic acid,

(b) sinapinic acid and, optionally,

(c) polyphenols,

with the proviso that components (a) and (b) are present in a weight ratio of about 85:15 to 98:2.

2. The composition of claim 1 , wherein it contains components (a+b) and (c) in a weight ratio of about 5:95 to about 1:99.

3. An extract, comprising

(a) caffeic acid,

(b) sinapinic acid and, optionally,

(c) polyphenols,

with the proviso that components (a) and (b) are present in a weight ratio of about 85:15 to about 98:2.

4. The extract of claim 3 , wherein it comprises

(a) 150 to 1.000 ppm caffeic acid,

(b) 10 to 50 ppm sinapinic acid, and

(c) 10 to 60% by weight polyphenols, and

is essentially filled up to 100% by weight with solvents.

5. The extract of claim 3 , wherein has a total content of hydroxycinnamic acids of about 0.5 to about 3% by weight.

6. The extract of claim 3 , wherein is obtained from plants or fruits selected from the group consisting of Açai ( Euterpe oleracea ); Aronia (e.g. Aronia arbutifolia, Aronia melanocarpa; Aronia prunifolia ); black currants and red currants (e.g. Ribes rubrum, Ribes spciatum, Ribes alpinum, Ribes schlechtendalii, Ribes multiflorum, Ribes petraeurn, Ribes trite, Ribes nigrum ); blackberries ( Rubus sp.); black carrots ( Daucus carota ); black tomatoes ( Solarium lycopersicum ); blood oranges ( Citrus sinensis ); blueberries ( Vaccinium corymbosum, Vaccinium angustifolium ); black haw ( Prunus spinosa ); bilberries ( Vaccinium ulginosum ); cloudberries ( Rubus chamaemorous ); lingonberries (e.g. Vaccinium oxycoccos, Vaccinium microcarpus, Vaccinium macrocarpus, Vaccinium erythrocarpus ); black crowberries (e.g. Empetrum nigrum, Empetrum eamesil, Empetrum rumbrum, Empetrum hermaphroditum ); elderberries (e.g. Sambucus nigra, Sambucus racemase ); hibiscus ( Hibiscus sabdariffa, Roselle ); cowberries (e.g. Vaccinium vitas idaea ); Magellan barberries (“Calafate”), Berberis microphylla, Breberis buxifolia ); Maqui berries (e.g. Aristotelia chilensis ) mountain huckleberries ( Vaccinium membranaceum ); plums and damsons ( Prunus domestica ); raspberries ( Rufous idaeus, Rubus occidentalis ); red gooseberries ( Ribes uva - crispa, Ribes grossularia ); red grapes ( Vitis vinifera, Vitis labrusca, Vitis riparia, Vitis rotundifolia ); rowanberries ( Sorbus aucparia ); sour cherries ( Prunus avium, Prunus cerasus ); strawberries ( Fragaria ananassa ); sweet cherries ( Prunus avium ); tay berries ( Rubus X).

7. The extract of claim 3 , wherein it has

(a) an ORAC value of above 5,000 and/or

(b) a polyphenol content of above 40% by weight and/or

(c) an anthocyanine content of about 6 to about 25% by weight and/or

(d) an ash content of less than 3% by weight and/or

(e) a sugar content of less than 0.25% by weight.

8. A method of production of the extract of claim 3 , wherein

(i) a juice or an extract is produced from the plants or fruits, which is then acidified,

(ii) the acidified product is passed over an adsorber column which contains as adsorption means a macroporous, crosslinked, non-functionalized polystyrene resin,

(iii) the mixture comprising components (a), (b) and (c) is desorbed by means of aqueous alcohol and finally

(iv) the eluate is dried.

9. A food or a dietary supplement, comprising the composition of claim 1 .

10. A pharmaceutical composition for the protection of the human or animal body against oxidative damage, comprising the composition of claim 1 .

11. A cosmetic means, comprising the composition of claim 1 .

12. A method to improve the oxidative stability of food, wherein an effective amount of a composition of claim 1 is added to the food.

13. A non-therapeutic method for the protection of the human or animal body against oxidative damage, wherein said body is treated with an effective amount of a composition of claim 1 .

14. A food or a dietary supplement, comprising the extract of claim 2 .

15. A pharmaceutical composition for the protection of the human or animal body against oxidative damage, comprising the extract of claim 2 .

16. A cosmetic means, comprising the extract of claim 2 .

17. A method to improve the oxidative stability of food, wherein an effective amount of an extract of claim 2 is added to the food.

18. A non-therapeutic method for the protection of the human or animal body against oxidative damage, wherein said body is treated with an effective amount of an extract of claim 2 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2014
From: ERFURT, HARRY; SCHULD, RENE; STURTZ, MELANIE; WINTERMEYER, CHRISTIAN; NIEMEYER, HANS-JURGEN
To: SYMRISE AG
Reel/Frame 032879/0396 →
Priority Claims (1)
EP 13163647 · Apr 14, 2013 · regional
Continuity (1)
Related Publication 20140309294A1 · Oct 16, 2014